☰

John Christopher Hardy - Publications

Affiliations: 
1970-1997 Physics Chalk River Nuclear Laboratories 
 1997- Texas A & M University, College Station, TX, United States 
Area:
Nuclear physics
Website:
https://physics.tamu.edu/directory/john-hardy/
Tree Info Similar researchers PubMed Report error

172 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wu L, Real R, Martinez A, Chia R, Lawton MA, Shoai M, Bresner C, Hubbard L, Blauwendraat C, Singleton AB, Ryten M, Scholz SW, Traynor BJ, Williams N, Hu MTM, ... Hardy J, et al. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Medrxiv : the Preprint Server For Health Sciences. PMID 37987016 DOI: 10.1101/2023.10.17.23297157  0.363
2023 Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Hardy J, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311  0.332
2023 Arber C, Casey JM, Crawford S, Rambarack N, Yaman U, Wiethoff S, Augustin E, Piers TM, Rostagno A, Ghiso J, Lewis PA, Revesz T, Hardy J, Pocock JM, Houlden H, et al. Microglia produce the amyloidogenic ABri peptide in familial British dementia. Biorxiv : the Preprint Server For Biology. PMID 37425748 DOI: 10.1101/2023.06.27.546552  0.304
2023 Reynolds RH, Wagen AZ, Lona-Durazo F, Scholz SW, Shoai M, Hardy J, Gagliano Taliun SA, Ryten M. Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases. Npj Parkinson's Disease. 9: 70. PMID 37117178 DOI: 10.1038/s41531-023-00504-1  0.335
2023 Baker E, Leonenko G, Schmidt KM, Hill M, Myers AJ, Shoai M, de Rojas I, Tesi N, Holstege H, van der Flier WM, Pijnenburg YAL, Ruiz A, Hardy J, van der Lee S, Escott-Price V. What does heritability of Alzheimer's disease represent? Plos One. 18: e0281440. PMID 37115753 DOI: 10.1371/journal.pone.0281440  0.364
2023 Zhou X, Chen Y, Ip FCF, Jiang Y, Cao H, Lv G, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RMN, Tong EPS, Mok VCT, ... ... Hardy J, et al. Deep learning-based polygenic risk analysis for Alzheimer's disease prediction. Communications Medicine. 3: 49. PMID 37024668 DOI: 10.1038/s43856-023-00269-x  0.304
2023 Soreq L, Bird H, Mohamed W, Hardy J. Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression. Plos One. 18: e0277630. PMID 36827281 DOI: 10.1371/journal.pone.0277630  0.308
2022 Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VMN, Lau SF, Wu W, Wong DYK, Seo H, Fu WY, Lai NCH, Chen Y, Chen Y, Tong EPS, ... Hardy J, et al. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease. Nature Aging. 2: 616-634. PMID 37117777 DOI: 10.1038/s43587-022-00241-9  0.34
2022 Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, van Rooij JGJ, Sims R, Ahmad S, Amin N, Norsworthy PJ, Dols-Icardo O, Hummerich H, Kawalia A, Amouyel P, ... ... Hardy J, et al. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease. Nature Genetics. PMID 36411364 DOI: 10.1038/s41588-022-01208-7  0.341
2022 Real R, Martinez-Carrasco A, Reynolds RH, Lawton MA, Tan MMX, Shoai M, Corvol JC, Ryten M, Bresner C, Hubbard L, Brice A, Lesage S, Faouzi J, Elbaz A, Artaud F, ... Hardy J, et al. Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia. Brain : a Journal of Neurology. PMID 36348503 DOI: 10.1093/brain/awac414  0.384
2022 Soutar MPM, Melandri D, O'Callaghan B, Annuario E, Monaghan AE, Welsh NJ, D'Sa K, Guelfi S, Zhang D, Pittman A, Trabzuni D, Verboven AHA, Pan KS, Kia DA, Bictash M, ... Hardy J, et al. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain : a Journal of Neurology. PMID 36074904 DOI: 10.1093/brain/awac325  0.356
2022 Bracher-Smith M, Leonenko G, Baker E, Crawford K, Graham AC, Salih DA, Howell BW, Hardy J, Escott-Price V. Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis. Neurobiology of Aging. 119: 67-76. PMID 35977442 DOI: 10.1016/j.neurobiolaging.2022.07.009  0.339
2022 Stolp Andersen M, Tan M, Holtman IR, Hardy J, Pihlstrøm L. Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease. Annals of Clinical and Translational Neurology. PMID 35684951 DOI: 10.1002/acn3.51606  0.337
2022 Escott-Price V, Hardy J. Genome-wide association studies for Alzheimer's disease: bigger is not always better. Brain Communications. 4: fcac125. PMID 35663382 DOI: 10.1093/braincomms/fcac125  0.335
2022 Stevenson-Hoare J, Heslegrave A, Leonenko G, Fathalla D, Bellou E, Luckcuck L, Marshall R, Sims R, Morgan BP, Hardy J, de Strooper B, Williams J, Zetterberg H, Escott-Price V. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain : a Journal of Neurology. PMID 35383826 DOI: 10.1093/brain/awac128  0.364
2022 Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, ... Hardy J, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics. PMID 35379992 DOI: 10.1038/s41588-022-01024-z  0.355
2022 Karlsson IK, Escott-Price V, Gatz M, Hardy J, Pedersen NL, Shoai M, Reynolds CA. Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins. Brain Communications. 4: fcab308. PMID 35169705 DOI: 10.1093/braincomms/fcab308  0.336
2021 Magusali N, Graham AC, Piers TM, Panichnantakul P, Yaman U, Shoai M, Reynolds RH, Botia JA, Brookes KJ, Guetta-Baranes T, Bellou E, Bayram S, Sokolova D, Ryten M, Sala Frigerio C, ... ... Hardy J, et al. A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Brain : a Journal of Neurology. PMID 34619763 DOI: 10.1093/brain/awab337  0.354
2021 Xiromerisiou G, Bourinaris T, Houlden H, Lewis PA, Senkevich K, Hammer M, Federoff M, Khan A, Spanaki C, Hadjigeorgiou GM, Bonstanjopoulou S, Fidani L, Ermolaev A, Gan-Or Z, Singleton A, ... ... Hardy J, et al. SORL1 mutation in a Greek family with Parkinson's disease and dementia. Annals of Clinical and Translational Neurology. PMID 34506082 DOI: 10.1002/acn3.51433  0.371
2021 Chelban V, Breza M, Szaruga M, Vandrovcova J, Murphy D, Lee CJ, Alikhwan S, Bourinaris T, Vavougios G, Ilyas M, Halim SA, Al-Harrasi A, Kartanou C, Ronald C, Blumcke I, ... ... Hardy J, et al. Spastic paraplegia preceding -related familial Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12186. PMID 33969176 DOI: 10.1002/dad2.12186  0.307
2021 Najar J, van der Lee SJ, Joas E, Wetterberg H, Hardy J, Guerreiro R, Bras J, Waern M, Kern S, Zetterberg H, Blennow K, Skoog I, Zettergren A. Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12142. PMID 33532541 DOI: 10.1002/dad2.12142  0.303
2020 Tan MMX, Lawton MA, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, Kanavou S, Pollard MI, Hubbard L, Malek N, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, ... ... Hardy J, et al. Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33111402 DOI: 10.1002/mds.28342  0.307
2020 Altmann A, Scelsi MA, Shoai M, de Silva E, Aksman LM, Cash DM, Hardy J, Schott JM. A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond . Brain Communications. 2: fcz047. PMID 32226939 DOI: 10.1093/braincomms/fcz047  0.343
2020 Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, et al. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11: 667. PMID 32015339 DOI: 10.1038/S41467-019-14279-8  0.331
2020 Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, ... ... Hardy J, et al. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta Neuropathologica Communications. 8: 5. PMID 31996268 DOI: 10.1186/S40478-020-0879-Z  0.408
2019 Salih DA, Bayram S, Guelfi S, Reynolds RH, Shoai M, Ryten M, Brenton JW, Zhang D, Matarin M, Botia JA, Shah R, Brookes KJ, Guetta-Baranes T, Morgan K, Bellou E, ... ... Hardy J, et al. Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk. Brain Communications. 1: fcz022. PMID 32274467 DOI: 10.1093/braincomms/fcz022  0.318
2019 Piers TM, Cosker K, Mallach A, Johnson GT, Guerreiro R, Hardy J, Pocock JM. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907987 DOI: 10.1096/Fj.201902447R  0.362
2019 Hardy J. Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk. Frontiers in Neuroscience. 13: 1304. PMID 31866813 DOI: 10.3389/fnins.2019.01304  0.322
2019 Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, ... ... Hardy J, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain : a Journal of Neurology. PMID 31755958 DOI: 10.1093/Brain/Awz350  0.366
2019 Schneider SA, Tahirovic S, Hardy J, Strupp M, Bremova-Ertl T. Do heterozygous mutations of Niemann-Pick type C predispose to late-onset neurodegeneration: a review of the literature. Journal of Neurology. PMID 31701332 DOI: 10.1007/S00415-019-09621-5  0.337
2019 Reynolds RH, Hardy J, Ryten M, Gagliano Taliun SA. Informing disease modelling with brain-relevant functional genomic annotations. Brain : a Journal of Neurology. PMID 31603214 DOI: 10.1093/Brain/Awz295  0.305
2019 Sjödin S, Brinkmalm G, Öhrfelt A, Parnetti L, Paciotti S, Hansson O, Hardy J, Blennow K, Zetterberg H, Brinkmalm A. Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's disease. Alzheimer's Research & Therapy. 11: 82. PMID 31521194 DOI: 10.1186/S13195-019-0533-9  0.343
2019 Singleton A, Hardy J. Progress in the Genetic Analysis of Parkinson's Disease. Human Molecular Genetics. PMID 31518392 DOI: 10.1093/Hmg/Ddz183  0.329
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hardy J, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.301
2019 Hardy J, Escott-Price V. Genes, pathways and risk prediction in Alzheimer's disease. Human Molecular Genetics. PMID 31332445 DOI: 10.1093/Hmg/Ddz163  0.355
2019 Tan MMX, Malek N, Lawton MA, Hubbard L, Pittman AM, Joseph T, Hehir J, Swallow DMA, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Bresner C, Foltynie T, ... Hardy J, et al. Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study. Brain : a Journal of Neurology. PMID 31324919 DOI: 10.1093/Brain/Awz191  0.31
2019 Baker E, Sims R, Leonenko G, Frizzati A, Harwood JC, Grozeva D, Morgan K, Passmore P, Holmes C, Powell J, ... ... Hardy J, et al. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. Plos One. 14: e0218111. PMID 31283791 DOI: 10.1371/Journal.Pone.0218111  0.344
2019 Huentelman M, De Both M, Jepsen W, Piras IS, Talboom JS, Willeman M, Reiman EM, Hardy J, Myers AJ. Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers. Scientific Reports. 9: 9640. PMID 31270419 DOI: 10.1038/S41598-019-45896-4  0.319
2019 Leonenko G, Shoai M, Bellou E, Sims R, Williams J, Hardy J, Escott-Price V. Genetic risk for Alzheimer's disease is distinct from genetic risk for amyloid deposition. Annals of Neurology. PMID 31199530 DOI: 10.1002/Ana.25530  0.304
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Hardy J, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/J.Nbd.2019.04.004  0.342
2019 Leonenko G, Sims R, Shoai M, Frizzati A, Bossù P, Spalletta G, Fox NC, Williams J, Hardy J, Escott-Price V. Polygenic risk and hazard scores for Alzheimer's disease prediction. Annals of Clinical and Translational Neurology. 6: 456-465. PMID 30911569 DOI: 10.1002/Acn3.716  0.305
2019 Startin CM, Ashton NJ, Hamburg S, Hithersay R, Wiseman FK, Mok KY, Hardy J, Lleó A, Lovestone S, Parnetti L, Zetterberg H, Hye A, Strydom A. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease. Alzheimer's Research & Therapy. 11: 26. PMID 30902060 DOI: 10.1186/S13195-019-0477-0  0.404
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hardy J, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.343
2019 Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, ... ... Hardy J, et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics. PMID 30617256 DOI: 10.1038/S41588-018-0311-9  0.352
2018 Nethisinghe S, Lim WN, Ging H, Zeitlberger A, Abeti R, Pemble S, Sweeney MG, Labrum R, Cervera C, Houlden H, Rosser E, Limousin P, Kennedy A, Lunn MP, Bhatia KP, ... ... Hardy J, et al. Complexity of the Genetics and Clinical Presentation of Spinocerebellar Ataxia 17. Frontiers in Cellular Neuroscience. 12: 429. PMID 30532692 DOI: 10.3389/Fncel.2018.00429  0.309
2018 Startin CM, Hamburg S, Hithersay R, Al-Janabi T, Mok KY, Hardy J, Strydom A. Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30503169 DOI: 10.1016/J.Jalz.2018.08.009  0.36
2018 Hithersay R, Startin CM, Hamburg S, Mok KY, Hardy J, Fisher EMC, Tybulewicz VLJ, Nizetic D, Strydom A. Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years. Jama Neurology. PMID 30452522 DOI: 10.1001/Jamaneurol.2018.3616  0.35
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Hardy J, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/J.Neurobiolaging.2018.10.019  0.309
2018 Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, Glaab E, Bobbili DR, Antony P, Koegelsberger S, Kurz A, Grimmer T, Morgan K, Vardarajan BN, Reitz C, Hardy J, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Molecular Psychiatry. PMID 29988083 DOI: 10.1038/S41380-018-0091-8  0.437
2018 Firth NC, Startin CM, Hithersay R, Hamburg S, Wijeratne PA, Mok KY, Hardy J, Alexander DC, Strydom A. Aging related cognitive changes associated with Alzheimer's disease in Down syndrome. Annals of Clinical and Translational Neurology. 5: 741-751. PMID 29928657 DOI: 10.1002/Acn3.571  0.414
2018 Ferrari R, Kia DA, Tomkins JE, Hardy J, Wood NW, Lovering RC, Lewis PA, Manzoni C. Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis. Bmc Genomics. 19: 452. PMID 29898659 DOI: 10.1186/S12864-018-4804-9  0.33
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... Hardy J, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.412
2018 Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, et al. CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry. 8: 73. PMID 29636460 DOI: 10.1038/S41398-017-0049-7  0.468
2018 Strydom A, Heslegrave A, Startin CM, Mok KY, Hardy J, Groet J, Nizetic D, Zetterberg H. Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome. Alzheimer's Research & Therapy. 10: 39. PMID 29631614 DOI: 10.1186/S13195-018-0367-X  0.358
2018 Brownjohn PW, Smith J, Solanki R, Lohmann E, Houlden H, Hardy J, Dietmann S, Livesey FJ. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem Cell Reports. PMID 29606617 DOI: 10.1016/J.Stemcr.2018.03.003  0.335
2018 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Hardy J, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015  0.356
2018 Carmona S, Hardy J, Guerreiro R. The genetic landscape of Alzheimer disease. Handbook of Clinical Neurology. 148: 395-408. PMID 29478590 DOI: 10.1016/B978-0-444-64076-5.00026-0  0.389
2018 Pasanen P, Myllykangas L, Pöyhönen M, Kiviharju A, Siitonen M, Hardy J, Bras J, Paetau A, Tienari PJ, Guerreiro R, Verkkoniemi-Ahola A. Genetics of dementia in a Finnish cohort. European Journal of Human Genetics : Ejhg. PMID 29476165 DOI: 10.1038/S41431-018-0117-3  0.443
2018 Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Frontiers in Aging Neuroscience. 10: 7. PMID 29441010 DOI: 10.3389/Fnagi.2018.00007  0.353
2018 Zhou X, Chen Y, Mok KY, Zhao Q, Chen K, Chen Y, Hardy J, Li Y, Fu AKY, Guo Q, Ip NY. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432188 DOI: 10.1073/Pnas.1715554115  0.32
2018 Malek N, Weil RS, Bresner C, Lawton MA, Grosset KA, Tan M, Bajaj N, Barker RA, Burn DJ, Foltynie T, Hardy J, Wood NW, Ben-Shlomo Y, Williams NW, Grosset DG, et al. Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29378790 DOI: 10.1136/Jnnp-2017-317348  0.377
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... Hardy J, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7  0.415
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Hardy J, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  0.307
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... Hardy J, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1  0.425
2017 Chaudhury S, Patel T, Barber IS, Guetta-Baranes T, Brookes KJ, Chappell S, Turton J, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann D, Morgan K. Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease. Neurobiology of Aging. PMID 29103623 DOI: 10.1016/J.Neurobiolaging.2017.09.035  0.359
2017 Darwent L, Carmona S, Lohmann E, Guven G, Kun-Rodrigues C, Bilgic B, Hanagasi H, Gurvit H, Erginel-Unaltuna N, Pak M, Hardy J, Singleton A, Brás J, Guerreiro R. Mutations in TYROBP are not a common cause of dementia in a Turkish cohort. Neurobiology of Aging. PMID 28716534 DOI: 10.1016/J.Neurobiolaging.2017.06.019  0.322
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Hardy J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.317
2017 Mishra A, Ferrari R, Heutink P, Hardy J, Pijnenburg Y, Posthuma D. Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia. Brain : a Journal of Neurology. PMID 28387812 DOI: 10.1093/Brain/Awx066  0.334
2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Hardy J, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258  0.327
2017 Ferrari R, Grassi M, Graziano F, Palluzzi F, Archetti S, Bonomi E, Bruni AC, Maletta RG, Bernardi L, Cupidi C, Colao R, Rainero I, Rubino E, Pinessi L, Galimberti D, ... ... Hardy J, et al. Effects of Multiple Genetic Loci on Age at Onset in Frontotemporal Dementia. Journal of Alzheimer's Disease : Jad. PMID 28128768 DOI: 10.3233/Jad-160949  0.384
2017 Hardy J. The Discovery of Alzheimer causing Mutations in the APP Gene and the Formulation of the "Amyloid Cascade Hypothesis". The Febs Journal. PMID 28054745 DOI: 10.1111/Febs.14004  0.318
2016 Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M, Weale ME. Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases. Annals of Clinical and Translational Neurology. 3: 924-933. PMID 28097204 DOI: 10.1002/Acn3.369  0.418
2016 Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, Momeni P, Schellenberg GS, Dillon WP, ... ... Hardy J, et al. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27899424 DOI: 10.1136/Jnnp-2016-314411  0.373
2016 Barber IS, Braae A, Clement N, Patel T, Guetta-Baranes T, Brookes K, Medway C, Chappell S, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann DM, et al. Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array. Neurobiology of Aging. PMID 27776828 DOI: 10.1016/J.Neurobiolaging.2016.09.008  0.337
2016 Bras J, Djaldetti R, Alves AM, Mead S, Darwent L, Lleo A, Molinuevo JL, Blesa R, Singleton A, Hardy J, Clarimon J, Guerreiro R. Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer's disease identifies a homozygous CTSF mutation. Neurobiology of Aging. PMID 27524508 DOI: 10.1016/J.Neurobiolaging.2016.06.018  0.377
2016 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Hardy J, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/J.Neurobiolaging.2016.04.004  0.324
2016 Kara E, Tucci A, Manzoni C, Lynch DS, Elpidorou M, Bettencourt C, Chelban V, Manole A, Hamed SA, Haridy NA, Federoff M, Preza E, Hughes D, Pittman A, Jaunmuktane Z, ... ... Hardy J, et al. Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain : a Journal of Neurology. PMID 27217339 DOI: 10.1093/Brain/Aww111  0.312
2016 Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Yong KX, Lehmann M, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Murray ME, Khan QU, Petersen RC, Dickson DW, ... ... Hardy J, et al. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26993346 DOI: 10.1016/J.Jalz.2016.01.010  0.344
2016 Mattsson N, Schott JM, Hardy J, Turner MR, Zetterberg H. Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 26746185 DOI: 10.1136/Jnnp-2015-311321  0.32
2016 Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M, Weale M. Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's Annals of Clinical and Translational Neurology. DOI: 10.1101/059519  0.331
2015 Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, ... ... Hardy J, et al. Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. PMID 26643944 DOI: 10.1016/J.Neurobiolaging.2015.10.028  0.355
2015 Heywood WE, Galimberti D, Bliss E, Sirka E, Paterson RW, Magdalinou NK, Carecchio M, Reid E, Heslegrave A, Fenoglio C, Scarpini E, Schott JM, Fox NC, Hardy J, Bahtia K, et al. Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay. Molecular Neurodegeneration. 10: 64. PMID 26627638 DOI: 10.1186/S13024-015-0059-Y  0.309
2015 Villegas-Llerena C, Phillips A, Reitboeck PG, Hardy J, Pocock JM. Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease. Current Opinion in Neurobiology. 36: 74-81. PMID 26517285 DOI: 10.1016/J.Conb.2015.10.004  0.345
2015 Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, ... ... Hardy J, et al. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain : a Journal of Neurology. PMID 26490334 DOI: 10.1093/Brain/Awv268  0.321
2015 Wiseman FK, Al-Janabi T, Hardy J, Karmiloff-Smith A, Nizetic D, Tybulewicz VL, Fisher EM, Strydom A. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature Reviews. Neuroscience. 16: 564-74. PMID 26243569 DOI: 10.1038/Nrn3983  0.346
2015 Ferrari R, Grassi M, Salvi E, Borroni B, Palluzzi F, Pepe D, D'Avila F, Padovani A, Archetti S, Rainero I, Rubino E, Pinessi L, Benussi L, Binetti G, Ghidoni R, ... ... Hardy J, et al. A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia. Neurobiology of Aging. 36: 2904.e13-26. PMID 26154020 DOI: 10.1016/J.Neurobiolaging.2015.06.005  0.314
2015 Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, ... ... Hardy J, et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26092349 DOI: 10.1016/J.Jalz.2015.02.012  0.312
2015 Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, ... ... Hardy J, et al. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 131: 2061-9. PMID 25862742 DOI: 10.1161/Circulationaha.115.015489  0.324
2015 Guerreiro R, Bras J, Toombs J, Heslegrave A, Hardy J, Zetterberg H. Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease. Current Genetic Medicine Reports. 3: 19-25. PMID 25664224 DOI: 10.1007/S40142-014-0062-6  0.351
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Hardy J, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.314
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/Journal.Pgen.1004606  0.338
2014 Guerreiro R, Hardy J. Genetics of Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 732-7. PMID 25113539 DOI: 10.1007/S13311-014-0295-9  0.362
2014 Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Al-Sarraj S, Niblock M, Gallo JM, Adnan J, Killick R, Brown KS, Medway C, Lord J, Turton J, ... ... Hardy J, et al. Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease. Neurobiology of Aging. 35: 2881.e1-6. PMID 25104557 DOI: 10.1016/J.Neurobiolaging.2014.06.002  0.384
2014 Mencacci NE, Isaias IU, Reich MM, Ganos C, Plagnol V, Polke JM, Bras J, Hersheson J, Stamelou M, Pittman AM, Noyce AJ, Mok KY, Opladen T, Kunstmann E, Hodecker S, ... ... Hardy J, et al. Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a Journal of Neurology. 137: 2480-92. PMID 24993959 DOI: 10.1093/Brain/Awu179  0.302
2014 Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, ... ... Hardy J, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. 6: 243ra86. PMID 24990881 DOI: 10.1126/Scitranslmed.3009093  0.34
2014 Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, ... ... Hardy J, et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human Molecular Genetics. 23: 6139-46. PMID 24973356 DOI: 10.1093/Hmg/Ddu334  0.366
2014 Guerreiro R, Brás J, Wojtas A, Rademakers R, Hardy J, Graff-Radford N. A nonsense mutation in PRNP associated with clinical Alzheimer's disease. Neurobiology of Aging. 35: 2656.e13-6. PMID 24958194 DOI: 10.1016/J.Neurobiolaging.2014.05.013  0.3
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Hardy J, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661  0.341
2014 Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Mann D, Snowden J, Neary D, ... ... Hardy J, et al. Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiology of Aging. 35: 2422.e13-6. PMID 24880964 DOI: 10.1016/J.Neurobiolaging.2014.04.026  0.364
2014 Mok KY, Jones EL, Hanney M, Harold D, Sims R, Williams J, Ballard C, Hardy J. Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome. Neurobiology of Aging. 35: 1513.e1-5. PMID 24462566 DOI: 10.1016/J.Neurobiolaging.2013.12.022  0.3
2014 Karran E, Hardy J. Antiamyloid therapy for Alzheimer's disease--are we on the right road? The New England Journal of Medicine. 370: 377-8. PMID 24450897 DOI: 10.1056/Nejme1313943  0.32
2014 Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Hardy J, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/J.Neurobiolaging.2013.12.010  0.33
2014 Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, ... ... Hardy J, ... ... Hardy J, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/Nature12825  0.336
2014 Ferrari R, Kero M, Mok K, Paetau A, Tienari PJ, Tynninen O, Hardy J, Momeni P, Verkkoniemi-Ahola A, Myllykangas L. Familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma. Neurobiology of Aging. 35: 444.e11-4. PMID 24080172 DOI: 10.1016/J.Neurobiolaging.2013.08.021  0.31
2013 Moskvina V, Harold D, Russo G, Vedernikov A, Sharma M, Saad M, Holmans P, Bras JM, Bettella F, Keller MF, Nicolaou N, Simón-Sánchez J, Gibbs JR, Schulte C, Durr A, ... ... Hardy J, et al. Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. Jama Neurology. 70: 1268-76. PMID 23921447 DOI: 10.1001/Jamaneurol.2013.448  0.313
2013 Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL. α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica. 125: 753-69. PMID 23404372 DOI: 10.1007/S00401-013-1096-7  0.303
2013 Scahill RI, Ridgway GR, Bartlett JW, Barnes J, Ryan NS, Mead S, Beck J, Clarkson MJ, Crutch SJ, Schott JM, Ourselin S, Warren JD, Hardy J, Rossor MN, Fox NC. Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations. Journal of Alzheimer's Disease : Jad. 35: 199-212. PMID 23380992 DOI: 10.3233/Jad-121255  0.308
2013 Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Ramirez-Restrepo M, ... ... Hardy J, et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Annals of Human Genetics. 77: 85-105. PMID 23360175 DOI: 10.1111/Ahg.12000  0.322
2013 Guerreiro RJ, Lohmann E, Brás JM, Gibbs JR, Rohrer JD, Gurunlian N, Dursun B, Bilgic B, Hanagasi H, Gurvit H, Emre M, Singleton A, Hardy J. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. Jama Neurology. 70: 78-84. PMID 23318515 DOI: 10.1001/Jamaneurol.2013.579  0.308
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, ... ... Hardy J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851  0.383
2013 Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, ... ... Hardy J, et al. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry. 18: 788-98. PMID 22889921 DOI: 10.1038/Mp.2012.85  0.317
2012 Swaminathan S, Huentelman MJ, Corneveaux JJ, Myers AJ, Faber KM, Foroud T, Mayeux R, Shen L, Kim S, Turk M, Hardy J, Reiman EM, Saykin AJ. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Plos One. 7: e50640. PMID 23227193 DOI: 10.1371/Journal.Pone.0050640  0.356
2012 Friedland RP, Shah JJ, Farrer LA, Vardarajan B, Rebolledo-Mendez JD, Mok K, Hardy J. Behavioral variant frontotemporal lobar degeneration with amyotrophic lateral sclerosis with a chromosome 9p21 hexanucleotide repeat. Frontiers in Neurology. 3: 136. PMID 23060854 DOI: 10.3389/Fneur.2012.00136  0.323
2012 Guerreiro RJ, Hardy J. TOMM40 association with Alzheimer disease: tales of APOE and linkage disequilibrium. Archives of Neurology. 69: 1243-4. PMID 22869030 DOI: 10.1001/Archneurol.2012.1935  0.337
2012 Hardy J, Revesz T. The spread of neurodegenerative disease. The New England Journal of Medicine. 366: 2126-8. PMID 22646635 DOI: 10.1056/Nejmcibr1202401  0.315
2012 Kara E, Ling H, Pittman AM, Shaw K, de Silva R, Simone R, Holton JL, Warren JD, Rohrer JD, Xiromerisiou G, Lees A, Hardy J, Houlden H, Revesz T. The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features. Neurobiology of Aging. 33: 2231.e7-2231.e14. PMID 22595371 DOI: 10.1016/J.Neurobiolaging.2012.04.006  0.353
2012 Simón-Sánchez J, Kilarski LL, Nalls MA, Martinez M, Schulte C, Holmans P, Gasser T, Hardy J, Singleton AB, Wood NW, Brice A, Heutink P, Williams N, et al. Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease. Plos One. 7: e28787. PMID 22427796 DOI: 10.1371/Journal.Pone.0028787  0.324
2012 Dobricic V, Stefanova E, Jankovic M, Gurunlian N, Novakovic I, Hardy J, Kostic V, Guerreiro R. Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort. Neurobiology of Aging. 33: 1481.e7-12. PMID 22221884 DOI: 10.1016/J.Neurobiolaging.2011.12.007  0.338
2012 Majounie E, Abramzon Y, Renton AE, Perry R, Bassett SS, Pletnikova O, Troncoso JC, Hardy J, Singleton AB, Traynor BJ. Repeat expansion in C9ORF72 in Alzheimer's disease. The New England Journal of Medicine. 366: 283-4. PMID 22216764 DOI: 10.1056/Nejmc1113592  0.356
2012 Setó-Salvia N, Pagonabarraga J, Houlden H, Pascual-Sedano B, Dols-Icardo O, Tucci A, Paisán-Ruiz C, Campolongo A, Antón-Aguirre S, Martín I, Muñoz L, Bufill E, Vilageliu L, Grinberg D, Cozar M, ... ... Hardy J, et al. Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 393-9. PMID 22173904 DOI: 10.1002/Mds.24045  0.353
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Hardy J, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824  0.399
2012 Crehan H, Holton P, Wray S, Pocock J, Guerreiro R, Hardy J. Complement receptor 1 (CR1) and Alzheimer's disease. Immunobiology. 217: 244-50. PMID 21840620 DOI: 10.1016/J.Imbio.2011.07.017  0.337
2012 McNaughton D, Knight W, Guerreiro R, Ryan N, Lowe J, Poulter M, Nicholl DJ, Hardy J, Revesz T, Lowe J, Rossor M, Collinge J, Mead S. Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiology of Aging. 33: 426.e13-21. PMID 21193246 DOI: 10.1016/J.Neurobiolaging.2010.10.010  0.31
2012 Guerreiro RJ, Gustafson DR, Hardy J. The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiology of Aging. 33: 437-56. PMID 20594621 DOI: 10.1016/J.Neurobiolaging.2010.03.025  0.363
2011 Rohrer JD, Lashley T, Schott JM, Warren JE, Mead S, Isaacs AM, Beck J, Hardy J, de Silva R, Warrington E, Troakes C, Al-Sarraj S, King A, Borroni B, Clarkson MJ, et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain : a Journal of Neurology. 134: 2565-81. PMID 21908872 DOI: 10.1093/Brain/Awr198  0.315
2011 Ferrari R, Hardy J, Momeni P. Frontotemporal dementia: from Mendelian genetics towards genome wide association studies. Journal of Molecular Neuroscience : Mn. 45: 500-15. PMID 21898125 DOI: 10.1007/S12031-011-9635-Y  0.311
2011 Devine MJ, Gwinn K, Singleton A, Hardy J. Parkinson's disease and α-synuclein expression. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2160-8. PMID 21887711 DOI: 10.1002/Mds.23948  0.348
2011 Singleton A, Hardy J. A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci. Human Molecular Genetics. 20: R158-62. PMID 21875901 DOI: 10.1093/Hmg/Ddr358  0.311
2011 Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R, Ivanov D, Pahwa JS, Moskvina V, Dowzell K, Thomas C, Stretton A, Lovestone S, ... ... Hardy J, et al. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 764-71. PMID 21812096 DOI: 10.1002/Ajmg.B.31216  0.357
2011 Guerreiro RJ, Hardy J. Alzheimer's disease genetics: lessons to improve disease modelling. Biochemical Society Transactions. 39: 910-6. PMID 21787322 DOI: 10.1042/Bst0390910  0.342
2011 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, ... ... Hardy J, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 43: 699-705. PMID 21685912 DOI: 10.1038/Ng.859  0.312
2011 Peuralinna T, Tanskanen M, Mäkelä M, Polvikoski T, Paetau A, Kalimo H, Sulkava R, Hardy J, Lai SL, Arepalli S, Hernandez D, Traynor BJ, Singleton A, Tienari PJ, Myllykangas L. APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis. Journal of Alzheimer's Disease : Jad. 26: 377-85. PMID 21654062 DOI: 10.3233/Jad-2011-102049  0.31
2011 Gasser T, Hardy J, Mizuno Y. Milestones in PD genetics. Movement Disorders. 26: 1042-1048. PMID 21626549 DOI: 10.1002/Mds.23637  0.367
2011 Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 377: 641-9. PMID 21292315 DOI: 10.1016/S0140-6736(10)62345-8  0.312
2010 Hardy J. Genetic Analysis of Pathways to Parkinson Disease Neuron. 68: 201-206. PMID 20955928 DOI: 10.1016/J.Neuron.2010.10.014  0.301
2010 Singleton AB, Hardy J, Traynor BJ, Houlden H. Towards a complete resolution of the genetic architecture of disease. Trends in Genetics : Tig. 26: 438-42. PMID 20813421 DOI: 10.1016/J.Tig.2010.07.004  0.315
2010 Zetzsche T, Rujescu D, Hardy J, Hampel H. Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease. Expert Review of Molecular Diagnostics. 10: 667-90. PMID 20629514 DOI: 10.1586/Erm.10.48  0.332
2010 Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, ... ... Hardy J, et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Human Molecular Genetics. 19: 3295-301. PMID 20534741 DOI: 10.1093/Hmg/Ddq221  0.309
2010 Guerreiro RJ, Beck J, Gibbs JR, Santana I, Rossor MN, Schott JM, Nalls MA, Ribeiro H, Santiago B, Fox NC, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J. Genetic variability in CLU and its association with Alzheimer's disease. Plos One. 5: e9510. PMID 20209083 DOI: 10.1371/Journal.Pone.0009510  0.33
2009 Blom ES, Giedraitis V, Arepalli S, Hamshere ML, Adighibe O, Goate A, Williams J, Lannfelt L, Hardy J, Vrièze FW, Glaser A. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. Bmc Medical Genetics. 10: 122. PMID 19951422 DOI: 10.1186/1471-2350-10-122  0.316
2009 Hardy J, Lewis P, Revesz T, Lees A, Paisan-Ruiz C. The genetics of Parkinson's syndromes: a critical review. Current Opinion in Genetics & Development. 19: 254-65. PMID 19419854 DOI: 10.1016/J.Gde.2009.03.008  0.305
2009 Neumann J, Bras J, Deas E, O'Sullivan SS, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, Segarane B, Singleton A, Lees A, Hardy J, Houlden H, et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain : a Journal of Neurology. 132: 1783-94. PMID 19286695 DOI: 10.1093/Brain/Awp044  0.321
2008 Bras J, Singleton A, Cookson MR, Hardy J. Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease. The Febs Journal. 275: 5767-73. PMID 19021754 DOI: 10.1111/J.1742-4658.2008.06709.X  0.306
2008 Webster JA, Myers AJ, Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL, Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura K, ... ... Hardy J, et al. Sorl1 as an Alzheimer's disease predisposition gene? Neuro-Degenerative Diseases. 5: 60-4. PMID 17975299 DOI: 10.1159/000110789  0.347
2007 De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 9434-9. PMID 17517621 DOI: 10.1073/Pnas.0603523104  0.328
2007 Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, ... ... Hardy J, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. The Journal of Clinical Psychiatry. 68: 613-8. PMID 17474819 DOI: 10.4088/Jcp.V68N0419  0.343
2007 Brown AM, Gordon D, Lee H, Wavrant-De Vrièze F, Cellini E, Bagnoli S, Nacmias B, Sorbi S, Hardy J, Blass JP. Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations. Neurochemical Research. 32: 857-69. PMID 17342416 DOI: 10.1007/S11064-006-9235-3  0.324
2007 Hardy J, Myers A. Genetic variability in expression of proteins and the risk of sporadic neurologic diseases Neurology. 68: 632-633. PMID 17325268 DOI: 10.1212/01.Wnl.0000256793.58438.C4  0.339
2007 Wavrant-De Vrièze F, Compton D, Womick M, Arepalli S, Adighibe O, Li L, Pérez-Tur J, Hardy J. ABCA1 polymorphisms and Alzheimer's disease. Neuroscience Letters. 416: 180-3. PMID 17324514 DOI: 10.1016/J.Neulet.2007.02.010  0.311
2006 Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. Journal of Alzheimer's Disease. 9: 151-153. PMID 16914853 DOI: 10.3233/Jad-2006-9S317  0.304
2006 Guerreiro RJ, Bras JM, Santana I, Januario C, Santiago B, Morgadinho AS, Ribeiro MH, Hardy J, Singleton A, Oliveira C. Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. Bmc Neurology. 6: 24. PMID 16824219 DOI: 10.1186/1471-2377-6-24  0.347
2006 Hardy J, Orr H. The genetics of neurodegenerative diseases Journal of Neurochemistry. 97: 1690-1699. PMID 16805777 DOI: 10.1111/J.1471-4159.2006.03979.X  0.306
2006 Hardy J, Pittman A, Myers A, Fung HC, de Silva R, Duckworth J. Tangle diseases and the tau haplotypes. Alzheimer Disease and Associated Disorders. 20: 60-2. PMID 16493238 DOI: 10.1097/01.Wad.0000201853.54493.D8  0.317
2006 Adighibe O, Arepalli S, Duckworth J, Hardy J, Vrièze FW. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease. Neurobiology of Aging. 27: 1431-1434. PMID 16207502 DOI: 10.1016/J.Neurobiolaging.2005.08.010  0.328
2006 Momeni P, Cairns NJ, Perry RH, Bigio EH, Gearing M, Singleton AB, Hardy J. Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID). Neurobiology of Aging. 27: 778.e1-778.e6. PMID 16005115 DOI: 10.1016/J.Neurobiolaging.2005.03.030  0.308
2006 Hardy J. The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease. Annals of the New York Academy of Sciences. 991: 167-170. PMID 12846985 DOI: 10.1111/J.1749-6632.2003.Tb07474.X  0.306
2005 Hernandez D, Ruiz CP, Crawley A, Malkani R, Werner J, Gwinn-Hardy K, Dickson D, DeVrieze FW, Hardy J, Singleton A. The dardarin G2019S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases Neuroscience Letters. 389: 137-139. PMID 16102903 DOI: 10.1016/J.Neulet.2005.07.044  0.327
2005 Clarimon J, Asgeirsson H, Singleton A, Jakobsson F, Hjaltason H, Hardy J, Sveinbjornsdottir S. Torsin A haplotype predisposes to idiopathic dystonia. Annals of Neurology. 57: 765-7. PMID 15852391 DOI: 10.1002/Ana.20485  0.304
2005 Li Y, Hollingworth P, Moore P, Foy C, Archer N, Powell J, Nowotny P, Holmans P, O'Donovan M, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Lau K, ... ... Hardy J, et al. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation. 25: 270-7. PMID 15714520 DOI: 10.1002/Humu.20138  0.324
2004 Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, ... ... Hardy J, et al. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proceedings of the National Academy of Sciences of the United States of America. 101: 15688-93. PMID 15507493 DOI: 10.1073/Pnas.0403535101  0.335
2004 Brown AM, Gordon D, Lee H, Caudy M, Hardy J, Haroutunian V, Blass JP. Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 131: 60-6. PMID 15389771 DOI: 10.1002/Ajmg.B.30008  0.307
2004 Dogu O, Johnson J, Hernandez D, Hanson M, Hardy J, Apaydin H, Özekmekçi S, Sevim S, Gwinn-Hardy K, Singleton A. A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 812-816. PMID 15254940 DOI: 10.1002/Mds.20028  0.307
2004 Coleman P, Kurlan R, Crook R, Werner J, Hardy J. A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5 Neuroscience Letters. 364: 139-140. PMID 15196662 DOI: 10.1016/J.Neulet.2004.04.030  0.312
2004 Singleton A, Myers A, Hardy J. The law of mass action applied to neurodegenerative disease: A hypothesis concerning the etiology and pathogenesis of complex diseases Human Molecular Genetics. 13: R123-R126. PMID 14976159 DOI: 10.1093/Hmg/Ddh093  0.353
2003 Hardy J. Impact of genetic analysis on Parkinson's disease research. Movement Disorders. 18: 96-98. PMID 14502662 DOI: 10.1002/Mds.10569  0.316
2003 Hardy J. Alzheimer's disease: genetic evidence points to a single pathogenesis. Annals of Neurology. 54: 143-144. PMID 12891664 DOI: 10.1002/Ana.10624  0.331
2003 Rippon GA, Crook R, Baker M, Halvorsen E, Chin S, Hutton M, Houlden H, Hardy J, Lynch T. Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia. Archives of Neurology. 60: 884-8. PMID 12810495 DOI: 10.1001/Archneur.60.6.884  0.327
2003 Harold D, Peirce T, Moskvina V, Myers A, Jones S, Hollingworth P, Moore P, Lovestone S, Powell J, Foy C, Archer N, Walter S, Edmonson A, McIlroy S, Craig D, ... ... Hardy J, et al. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics. 113: 258-67. PMID 12759818 DOI: 10.1007/S00439-003-0960-2  0.314
2003 Frank RA, Galasko D, Hampel H, Hardy J, de Leon MJ, Mehta PD, Rogers J, Siemers E, Trojanowski JQ. Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease. Neurobiology of Aging. 24: 521-36. PMID 12714109 DOI: 10.1016/S0197-4580(03)00002-2  0.301
2002 de Silva R, Hardy J, Crook J, Khan N, Graham EA, Morris CM, Wood NW, Lees AJ. The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. Neuroscience Letters. 330: 201-3. PMID 12231446 DOI: 10.1016/S0304-3940(02)00742-5  0.354
2002 Fidani L, Compton D, Hardy J, Petersen RC, Tangalos E, Mirtsou V, Goulas A, De Vrieze FW. No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease. Neuroscience Letters. 322: 192-4. PMID 11897170 DOI: 10.1016/S0304-3940(02)00098-8  0.333
2001 Hardy J. The genetic causes of neurodegenerative diseases. Journal of Alzheimer's Disease. 3: 109-116. PMID 12214079 DOI: 10.3233/Jad-2001-3115  0.338
Show low-probability matches.