Holly A. Leddy, Ph.D.
Affiliations: | 2007 | Duke University, Durham, NC |
Area:
Biomedical, General, BiomechanicsGoogle:
"Holly Leddy"Parents
Sign in to add mentor| Farshid Guilak | grad student | 2007 | Duke | |
| (Diffusional properties of articular cartilage.) | ||||
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Publications
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| Willard VP, Leddy HA, Palmer D, et al. (2021) Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells (Dayton, Ohio) |
| Lee W, Nims RJ, Savadipour A, et al. (2021) Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Gilchrist CL, Leddy HA, Kaye L, et al. (2019) TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Proceedings of the National Academy of Sciences of the United States of America |
| Lee W, Leddy H, McNulty A, et al. (2016) Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression Biophysical Journal. 110: 349a |
| Zelenski NA, Leddy HA, Sanchez-Adams J, et al. (2015) Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1286-94 |
| McNulty AL, Leddy HA, Liedtke W, et al. (2015) TRPV4 as a therapeutic target for joint diseases. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 437-50 |
| Leddy HA, McNulty AL, Guilak F, et al. (2014) Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias. Rare Diseases (Austin, Tex.). 2: e962971 |
| Lee W, Leddy HA, Chen Y, et al. (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22 |
| Sanchez-Adams J, Leddy HA, McNulty AL, et al. (2014) The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Current Rheumatology Reports. 16: 451 |
| Leddy HA, McNulty AL, Lee SH, et al. (2014) Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2525-37 |