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D Thomas Rutkowski, Ph.D.

Affiliations: 
1998-2002 Physiology University of California, San Francisco, San Francisco, CA 
 2002-2008 Biological Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
 2008- Anatomy and Cell Biology University of Iowa Carver College of Medicine, Iowa City, IA, United States 
Area:
secretory pathway, cell biology, prions, cell-free systems, ER stress, steatohepatitis, liver disease
Website:
https://medicine.uiowa.edu/acb/profile/thomas-rutkowski
Google:
"D Rutkowski"
Bio:

Graduate training with Vishu Lingappa, UCSF, studying regulation of ER protein translocation
Postdoctoral training with Randal Kaufman, HHMI/University of Michigan, studying ER stress signaling
Independent position at University of Iowa studying ER stress signaling and steatohepatitis

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Parents

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Vishwanath Rao Lingappa grad student 2002 UCSF
 (A new role for signal sequences: Regulation of protein biogenesis at the endoplasmic reticulum.)
Randal J. Kaufman post-doc 2002-2008 University of Michigan (Chemistry Tree)

Children

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Angela M. Arensdorf grad student 2009-2013 University of Iowa Carver College of Medicine
Javier A. Gomez grad student 2011-2016 University of Iowa Carver College of Medicine

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Publications

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Gansemer ER, McCommis KS, Martino M, et al. (2020) NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis. Iscience. 23: 101116
Rutkowski DT. (2019) Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response. Febs Journal. 286: 356-378
Diedrichs DR, Gomez JA, Huang CS, et al. (2018) A data-entrained computational model for testing the regulatory logic of the vertebrate unfolded protein response. Molecular Biology of the Cell. mbcE17090565
Diedrichs DR, Gomez JA, Huang CS, et al. (2018) A data-entrained computational model for testing the regulatory logic of the vertebrate unfolded protein response. Mol Biol Cell.. 29: 1502-1517
DeZwaan-McCabe D, Sheldon RD, Gorecki MC, et al. (2017) ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Reports. 19: 1794-1806
DeZwaan-McCabe D, Sheldon RD, Gorecki MC, et al. (2017) ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Rep. 19: 1794-1806
Gomez JA, Rutkowski DT. (2016) Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. Elife. 5
Gomez JA, Rutkowski DT. (2016) Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. Elife. 5: e20390
Gomez JA, Rutkowski DT. (2016) Author response: Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression Elife
Jo F, Jo H, Hilzendeger AM, et al. (2015) Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension. 65: 1341-8
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