Luigi Lamorte, Ph.D.

Affiliations: 
2003 McGill University, Montreal, QC, Canada 
Area:
Signal Transduction
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"Luigi Lamorte"

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Morag Park grad student 2003 McGill
 (A role for the Crk adaptor protein in cell transformation, epithelial cell dispersal and invasion.)
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Publications

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Lamorte L, Park M. (2003) ARF1 and ARF6 are dispensable for Crk-dependent epithelial-mesenchymal-like transitions. Anticancer Research. 23: 2085-92
Lamorte L, Rodrigues S, Sangwan V, et al. (2003) Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Molecular Biology of the Cell. 14: 2818-31
Lamorte L, Rodrigues S, Naujokas M, et al. (2002) Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program. The Journal of Biological Chemistry. 277: 37904-11
Lamorte L, Royal I, Naujokas M, et al. (2002) Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Molecular Biology of the Cell. 13: 1449-61
Peschard P, Fournier TM, Lamorte L, et al. (2001) Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Molecular Cell. 8: 995-1004
Lamorte L, Park M. (2001) The receptor tyrosine kinases: role in cancer progression. Surgical Oncology Clinics of North America. 10: 271-88, viii
Lamorte L, Kamikura DM, Park M. (2000) A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein. Oncogene. 19: 5973-81
Fournier TM, Lamorte L, Maroun CR, et al. (2000) Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion. Molecular Biology of the Cell. 11: 3397-410
Royal I, Lamarche-Vane N, Lamorte L, et al. (2000) Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Molecular Biology of the Cell. 11: 1709-25
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