Jacob E. Lazarus, Ph.D.
Affiliations: | 2012 | Cell and Molecular Biology | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Cytoskeleton, dynein, cell polarityGoogle:
"Jacob Lazarus"Parents
Sign in to add mentor| Erika L. F. Holzbaur | grad student | 2012 | Penn | |
| (Cytoplasmic dynein and dynactin coordinate microtubule dynamics at the growing plus end.) | ||||
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Publications
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| Pacheco AR, Lazarus JE, Sit B, et al. (2018) CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. Mbio. 9 |
| Nirschl JJ, Magiera MM, Lazarus JE, et al. (2016) α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Reports |
| Thom CS, Traxler EA, Khandros E, et al. (2014) Trim58 degrades Dynein and regulates terminal erythropoiesis. Developmental Cell. 30: 688-700 |
| Ayloo S, Lazarus JE, Dodda A, et al. (2014) Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nature Communications. 5: 4807 |
| Perlson E, Hendricks AG, Lazarus JE, et al. (2013) Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons. The Journal of Biological Chemistry. 288: 27812-24 |
| Moughamian AJ, Osborn GE, Lazarus JE, et al. (2013) Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13190-203 |
| Lazarus JE, Moughamian AJ, Tokito MK, et al. (2013) Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. Plos Biology. 11: e1001611 |
| Zhang J, Twelvetrees AE, Lazarus JE, et al. (2013) Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken, N.J.). 70: 215-27 |
| Lazarus JE, Moughamian AJ, Tokito MK, et al. (2013) p150Glued Regulates Microtubule Dynamics in Neurons through Tandem Tubulin-Binding Domains Biophysical Journal. 104: 146a |
| Hendricks AG, Lazarus JE, Perlson E, et al. (2012) Dynein tethers and stabilizes dynamic microtubule plus ends. Current Biology : Cb. 22: 632-7 |