Hans D. Brightbill, Ph.D.
Affiliations: | 2000 | University of California, Los Angeles, Los Angeles, CA |
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"Hans Brightbill"Parents
Sign in to add mentor| Stephen Todd Smale | grad student | 2000 | UCLA (Chemistry Tree) | |
| (Molecular mechanisms of the innate immune response: Regulation of IL-12 and IL-10 gene expression in macrophages.) | ||||
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Publications
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| Cai XT, Jia M, Heigl T, et al. (2024) IL-4-induced SOX9 confers lineage plasticity to aged adult lung stem cells. Cell Reports. 43: 114569 |
| Corzo CA, Varfolomeev E, Setiadi AF, et al. (2020) The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells. Science Signaling. 13 |
| Rajapaksa NS, Gobbi A, Drobnick J, et al. (2020) Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Medicinal Chemistry Letters. 11: 327-333 |
| Jie Z, Yang JY, Gu M, et al. (2018) NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature Immunology |
| Blaquiere N, Castanedo G, Burch J, et al. (2018) A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry |
| Brightbill HD, Suto E, Blaquiere N, et al. (2018) NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications. 9: 179 |
| Castanedo GM, Blaquiere N, Beresini MH, et al. (2016) Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K). Journal of Medicinal Chemistry |
| Li Y, Wang H, Zhou X, et al. (2016) Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses. Scientific Reports. 6: 22115 |
| Katakam AK, Brightbill H, Franci C, et al. (2015) Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America |
| Brightbill HD, Jackman JK, Suto E, et al. (2015) Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation. Journal of Immunology (Baltimore, Md. : 1950) |