Sadie Wignall, Ph.D.

Affiliations: 
1997-2003 University of California, Berkeley, Berkeley, CA, United States 
 2004-2010 Stanford University, Palo Alto, CA 
 2011- Molecular Biosciences Northwestern University, Evanston, IL 
Area:
Spindle assembly and chromosome dynamics during oocyte meiosis
Website:
https://sites.northwestern.edu/wignall-lab/
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"Sadie Wignall"

Parents

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Rebecca Heald grad student 2003 UC Berkeley
 (Identification and characterization of proteins involved in spindle assembly in Xenopus egg extracts.)
Anne Villeneuve post-doc 2004-2010 Stanford

Children

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Amanda Davis-Roca grad student 2018 Fred Hutchinson Cancer Center
Timothy Mullen grad student 2019 MIT
Ian Wolff grad student 2014-2020 Northwestern (Evolution Tree)
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Publications

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Czajkowski ER, Zou Y, Divekar NS, et al. (2024) The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles. Plos Genetics. 20: e1011373
Narula JG, Wignall SM. (2024) Polo-like kinase 1 prevents excess microtubule polymerization in oocytes to ensure faithful meiosis. Biorxiv : the Preprint Server For Biology
Czajkowski ER, Divekar NS, Wignall SM. (2023) The doublecortin-family kinase ZYG-8 regulates motor activity to achieve proper force balance in acentrosomal spindles. Biorxiv : the Preprint Server For Biology
Cavin-Meza G, Mullen TJ, Czajkowski ER, et al. (2022) ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis. Plos Genetics. 18: e1010489
Horton HH, Divekar NS, Wignall SM. (2022) Newfound features of meiotic chromosome organization that promote efficient congression and segregation in oocytes. Molecular Biology of the Cell. mbcE22070297
Wolff ID, Hollis JA, Wignall SM. (2022) Acentrosomal spindle assembly and maintenance in oocytes requires a kinesin-12 non-motor microtubule interaction domain. Molecular Biology of the Cell. mbcE22020056
Mendoza AD, Sue A, Antipova O, et al. (2022) Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans†. Biology of Reproduction
Cavin-Meza G, Kwan MM, Wignall SM. (2022) Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in oocyte meiosis. Elife. 11
Wolff ID, Divekar NS, Wignall SM. (2022) Methods for Investigating Cell Division Mechanisms in C. elegans. Methods in Molecular Biology (Clifton, N.J.). 2415: 19-35
Divekar NS, Davis-Roca AC, Zhang L, et al. (2021) A degron-based strategy reveals new insights into Aurora B function in C. elegans. Plos Genetics. 17: e1009567
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