Brenda A. Schulman
Affiliations: | Cell Biology and Biochemistry | University of Tennessee Health Science Center, Memphis, TN, United States |
Area:
BiochemistryGoogle:
"Brenda Schulman"Parents
Sign in to add mentorPeter S. Kim | grad student | 1989-1996 | MIT (Chemistry Tree) |
Ed Harlow | post-doc | 1996-1998 | Massachusetts General Hospital Cancer Center (Neurotree) |
Nikola P. Pavletich | post-doc | 1998-2001 | Memorial Sloan Kettering Cancer Center (Chemistry Tree) |
Children
Sign in to add traineeMin Zhuang | grad student | 2009 | UTHSC |
Asad Taherbhoy | grad student | 2011 | UTHSC |
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Publications
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Scott DC, Dharuman S, Griffith E, et al. (2024) Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nature Communications. 15: 8829 |
Hennes E, Lucas B, Scholes NS, et al. (2024) Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3. Biorxiv : the Preprint Server For Biology |
Kagiou C, Cisneros JA, Farnung J, et al. (2024) Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation. Nature Communications. 15: 5409 |
Yi SA, Sepic S, Schulman BA, et al. (2024) mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway. Molecular Cell. 84: 2166-2184.e9 |
Gottemukkala KV, Chrustowicz J, Sherpa D, et al. (2024) Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell. 84: 1948-1963.e11 |
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, et al. (2024) Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nature Structural & Molecular Biology |
Gross A, Müller J, Chrustowicz J, et al. (2024) Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. Febs Letters |
Li J, Purser N, Liwocha J, et al. (2024) Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Molecular Cell |
Liwocha J, Li J, Purser N, et al. (2024) Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nature Structural & Molecular Biology |
Botsch JJ, Junker R, Sorgenfrei M, et al. (2024) Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nature Communications. 15: 410 |