Brenda A. Schulman

Affiliations: 
Cell Biology and Biochemistry University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Biochemistry
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"Brenda Schulman"

Parents

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Peter S. Kim grad student 1989-1996 MIT (Chemistry Tree)
Ed Harlow post-doc 1996-1998 Massachusetts General Hospital Cancer Center (Neurotree)
Nikola P. Pavletich post-doc 1998-2001 Memorial Sloan Kettering Cancer Center (Chemistry Tree)

Children

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Min Zhuang grad student 2009 UTHSC
Asad Taherbhoy grad student 2011 UTHSC

Collaborators

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R. Kip Guy collaborator 2007- (Chemistry Tree)
BETA: Related publications

Publications

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Scott DC, Dharuman S, Griffith E, et al. (2024) Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nature Communications. 15: 8829
Hennes E, Lucas B, Scholes NS, et al. (2024) Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3. Biorxiv : the Preprint Server For Biology
Kagiou C, Cisneros JA, Farnung J, et al. (2024) Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation. Nature Communications. 15: 5409
Yi SA, Sepic S, Schulman BA, et al. (2024) mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway. Molecular Cell. 84: 2166-2184.e9
Gottemukkala KV, Chrustowicz J, Sherpa D, et al. (2024) Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell. 84: 1948-1963.e11
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, et al. (2024) Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nature Structural & Molecular Biology
Gross A, Müller J, Chrustowicz J, et al. (2024) Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. Febs Letters
Li J, Purser N, Liwocha J, et al. (2024) Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Molecular Cell
Liwocha J, Li J, Purser N, et al. (2024) Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nature Structural & Molecular Biology
Botsch JJ, Junker R, Sorgenfrei M, et al. (2024) Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nature Communications. 15: 410
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