Michelle D. Larrea, Ph.D.

Affiliations: 
2008 University of Miami, Coral Gables, FL 
Area:
Molecular Biology, Cell Biology
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"Michelle Larrea"

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Joyce M. Slingerland grad student 2008 University of Miami
 (The story of the promiscuous substrate: An investigation on the role of the PI3K pathway in p27Kip1 regulation.)
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Publications

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Wander SA, Hong F, Zhao D, et al. (2010) Abstract 5137: The PI3K pathway regulates the actin cytoskeleton, tumor cell migration and metastasis via the atypical tumor suppressor p27 Cancer Research. 70: 5137-5137
Larrea MD, Wander SA, Slingerland JM. (2009) p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle (Georgetown, Tex.). 8: 3455-61
Larrea MD, Hong F, Wander SA, et al. (2009) RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proceedings of the National Academy of Sciences of the United States of America. 106: 9268-73
Larrea MD, Liang J, Da Silva T, et al. (2008) Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Molecular and Cellular Biology. 28: 6462-72
Hong F, Larrea MD, Doughty C, et al. (2008) mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Molecular Cell. 30: 701-11
Das M, Wiley DJ, Medina S, et al. (2007) Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p. Molecular Biology of the Cell. 18: 2090-101
Liang J, Shao SH, Xu ZX, et al. (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nature Cell Biology. 9: 218-24
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