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Adam P. Siebert, Ph.D.

Affiliations: 
2012 Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
General Biophysics, Physiology Biology
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"Adam Siebert"
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James K. Foskett grad student 2012 Penn
 (Convergent structural and functional evolution of CALHM ion channel with connexins and pannexins-innexins.)

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Publications

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Foskett JK, Ma Z, Siebert AP, et al. (2014) Calcium Homeostasis Modulator (CALHM) Ion Channels: Structure, Functions and Physiological Roles Membrane. 39: 41-47
Siebert AP, Ma Z, Grevet JD, et al. (2013) Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. The Journal of Biological Chemistry. 288: 6140-53
Ma Z, Taruno A, Siebert AP, et al. (2013) CALHM1 is an Extracellular Ca2+- and Voltage-Gated ATP Permeable Ion Channel Biophysical Journal. 104: 631a
Kopil CM, Siebert AP, Foskett JK, et al. (2012) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons. Journal of Neurochemistry. 123: 147-58
Ma Z, Siebert AP, Cheung KH, et al. (2012) Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America. 109: E1963-71
Kopil CM, Vais H, Cheung KH, et al. (2011) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. The Journal of Biological Chemistry. 286: 35998-6010
Siebert AP, Ma Z, Foskett JK. (2011) Permeation Properties of CALHM1 Biophysical Journal. 100: 94a
Ma Z, Siebert AP, Foskett JK. (2011) A novel Calcium Channel Induced by CALHM1 Expression Detects Levels of Extracellular Calcium Biophysical Journal. 100: 259a
Vais H, Siebert AP, Ma Z, et al. (2010) Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels. Biophysical Journal. 99: 407-16
Ma Z, Siebert AP, Grevet JD, et al. (2010) Biophysical Properties of Calcium Homeostasis Modulator 1 (CALHM1) Ion Channel Biophysical Journal. 98: 22a
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