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Brian J. Zarnegar, Ph.D.

Affiliations: 
2008 University of California, Los Angeles, Los Angeles, CA 
Area:
Molecular Biology, Immunology
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"Brian Zarnegar"
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Genhong Cheng grad student 2008 UCLA
 (The biological significance and molecular mechanism of TRAF3 suppression of the canonical and noncanonical NF-kappaB activation pathways.)

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Razani B, Zarnegar B, Ytterberg AJ, et al. (2010) Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Science Signaling. 3: ra41
Zarnegar BJ, Wang Y, Mahoney DJ, et al. (2008) Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nature Immunology. 9: 1371-8
Zarnegar B, Yamazaki S, He JQ, et al. (2008) Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proceedings of the National Academy of Sciences of the United States of America. 105: 3503-8
Oganesyan G, Saha SK, Pietras EM, et al. (2008) IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production. The Journal of Biological Chemistry. 283: 802-8
Cheng G, Zarnegar BJ, Wang Y, et al. (2008) SY-8 Noncanonical NF-κB activation requires the coordinated assembly of the cIAP1/2-NIK regulatory complex by TRAF2 and TRAF3 Cytokine. 43: 236
He JQ, Oganesyan G, Saha SK, et al. (2007) TRAF3 and its biological function. Advances in Experimental Medicine and Biology. 597: 48-59
He JQ, Saha SK, Kang JR, et al. (2007) Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. The Journal of Biological Chemistry. 282: 3688-94
He JQ, Zarnegar B, Oganesyan G, et al. (2006) Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. The Journal of Experimental Medicine. 203: 2413-8
Saha SK, Pietras EM, He JQ, et al. (2006) Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. The Embo Journal. 25: 3257-63
Oganesyan G, Saha SK, Guo B, et al. (2006) Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 439: 208-11
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