Michael L. Gleghorn, Ph.D.
Affiliations: | 2008 | Pennsylvania State University, State College, PA, United States |
Area:
Biochemistry, Molecular Biology, General BiophysicsGoogle:
"Michael Gleghorn"Parents
Sign in to add mentor| Katsuhiko Murakami | grad student | 2008 | Penn State | |
| (X-ray crystal structures explain DNA-hairpin promoter binding and de novo transcription initiation for the N4 virion RNA polymerase.) | ||||
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Publications
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| Jones SP, Goossen C, Lewis SD, et al. (2022) Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase-RNA complexes. Journal of Structural Biology: X. 6: 100066 |
| Pickard MAG, Brylow KB, Cisco LA, et al. (2020) Parallel poly(A) homo- and hetero-duplex formation detection with an adapted DNA nanoswitch technique. Rna (New York, N.Y.) |
| Visentin S, Cannone G, Doutch J, et al. (2019) A multi-pronged approach to understanding the form and function of hStaufen protein. Rna (New York, N.Y.) |
| Cho H, Rambout X, Gleghorn ML, et al. (2018) Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes & Development |
| Gleghorn ML, Maquat LE. (2014) 'Black sheep' that don't leave the double-stranded RNA-binding domain fold Trends in Biochemical Sciences. 39: 328-340 |
| Gleghorn ML, Gong C, Kielkopf CL, et al. (2013) Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay Nature Structural and Molecular Biology. 20: 515-524 |
| Park E, Gleghorn ML, Maquat LE. (2013) Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity Proceedings of the National Academy of Sciences of the United States of America. 110: 405-412 |
| Chen Y, Basu R, Gleghorn ML, et al. (2011) Time-resolved events on the reaction pathway of transcript initiation by a single-subunit RNA polymerase: Raman crystallographic evidence. Journal of the American Chemical Society. 133: 12544-55 |
| Gleghorn ML, Davydova EK, Basu R, et al. (2011) X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 108: 3566-71 |
| Gleghorn ML, Davydova EK, Rothman-Denes LB, et al. (2008) Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Molecular Cell. 32: 707-17 |