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Natalie Strynadka

Affiliations: 
Biochemistry and Molecular Biology University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
structure-based design of novel, therapeutically useful antibiotics and inhibitors of antibiotic-resistance mechanisms
Website:
http://www.biochem.ubc.ca/faculty/natalie-strynadka/
Google:
"Natalie Strynadka"
Bio:

http://www.hhmi.org/research/sirs/strynadka_bio.html

Cross-listing: Chemistry Tree

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Parents

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Michael N.G. James grad student 1990 University of Alberta (Chemistry Tree)
 (Probing molecular interactions at various levels of structural definition)

Children

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Steven R Ness research assistant 1997-2000 Univesity of British Columia (UBC) (Chemistry Tree)
Nathanael A Caveney grad student (Chemistry Tree)
Calvin Yip grad student UBC
Trevor F. Moraes post-doc UBC

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Publications

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Li FKK, Peters SC, Worrall LJ, et al. (2025) Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH. Nature Communications. 16: 3224
Sverak HE, Yaeger LN, Worrall LJ, et al. (2024) Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance. Nature Communications. 15: 9936
Bon CG, Grigg JC, Lee J, et al. (2024) Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. Journal of Structural Biology. 108086
Li FKK, Worrall LJ, Gale RT, et al. (2024) Cryo-EM analysis of TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. Science Advances. 10: eadj3864
Worrall LJ, Majewski DD, Strynadka NCJ. (2023) Structural Insights into Type III Secretion Systems of the Bacterial Flagellum and Injectisome. Annual Review of Microbiology. 77: 669-698
Lee J, Kenward C, Worrall LJ, et al. (2022) X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications. 13: 5196
Workman SD, Day J, Farha MA, et al. (2021) Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. Journal of Medicinal Chemistry
Caveney NA, Workman SD, Yan R, et al. (2021) CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution. Nature Communications. 12: 2775
Li FKK, Gale RT, Petrotchenko EV, et al. (2021) Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis. Journal of Structural Biology. 107733
Lyons BJE, Atkinson CE, Deng W, et al. (2021) Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: revealing the mechanism of effector translocation in the T3SS. Structure (London, England : 1993)
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