Raymond J. Deshaies
Affiliations: | 2017 | Biology | California Institute of Technology, Pasadena, CA |
| 2017- | Global Research | Amgen Inc., Thousand Oaks, CA, United States |
Area:
Ubiquitin-Dependent Proteolysis and Cell DivisionWebsite:
https://www.amgen.com/about/leadership/Google:
"Raymond J. Deshaies"Bio:
http://www.nasonline.org/member-directory/members/20038967.html
http://www.deshaieslab.com/ray-deshaies.html
DOI: 10.1073/pnas.1710346114
https://www.hhmi.org/scientists/raymond-j-deshaies
Parents
Sign in to add mentor| Randy W. Schekman | grad student | 1988 | UC Berkeley | |
| (Genes Required for Protein Translocation Into the Yeast Endoplasmic Reticulum) | ||||
| Marc W. Kirschner | post-doc | 1990-1994 | UCSF | |
Children
Sign in to add trainee| Reid M. Feldman | grad student | 2000 | Caltech |
| Yong Chi | grad student | 2001 | Caltech |
| Svetlana A. Lyapina | grad student | 2001 | Caltech |
| Wenying Shou | grad student | 2001 | Caltech |
| Ramzi I. Azzam | grad student | 2004 | Caltech |
| Kathleen M. Sakamoto | grad student | 2004 | Caltech |
| Xavier I. Ambroggio | grad student | 1999-2004 | Caltech |
| Angie S. Mah | grad student | 2005 | Caltech |
| Johannes Graumann | grad student | 2000-2006 | Caltech |
| Nazli Ghaboosi | grad student | 2007 | Caltech |
| Natalie Kolawa | grad student | 2013 | Caltech |
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Publications
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| Zhang Y, Jost M, Pak RA, et al. (2022) Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205608119 |
| Cable J, Weber-Ban E, Clausen T, et al. (2022) Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Annals of the New York Academy of Sciences |
| Porras-Yakushi TR, Reitsma JM, Sweredoski MJ, et al. (2021) In-depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted. Journal of Proteomics. 241: 104197 |
| Yang SJ, Jeon SJ, Van Nguyen T, et al. (2020) Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity. Biochimica Et Biophysica Acta. Molecular Cell Research. 118729 |
| Deshaies RJ, Pierce NW. (2020) Transfer of ubiquitin protein caught in the act. Nature. 578: 372-373 |
| Verma R, Mohl D, Deshaies RJ. (2020) Harnessing the Power of Proteolysis for Targeted Protein Inactivation. Molecular Cell |
| Reichermeier KM, Straube R, Reitsma JM, et al. (2020) PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Molecular Cell |
| Wang K, Deshaies RJ, Liu X. (2020) Assembly and Regulation of CRL Ubiquitin Ligases. Advances in Experimental Medicine and Biology. 1217: 33-46 |
| Blythe EE, Gates SN, Deshaies RJ, et al. (2019) Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing. Structure (London, England : 1993) |
| Li J, Zhang Y, Da Silva Sil Dos Santos B, et al. (2018) Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chemical Biology |