Lei Xu
Affiliations: | University of Rochester | University of Rochester, Rochester, NY |
Website:
http://www.urmc.rochester.edu/biomedical-genetics/faculty/xu-lab.cfmGoogle:
"Lei Xu"
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Publications
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| Sagers JE, Beauchamp RL, Zhang Y, et al. (2020) Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma. Scientific Reports. 10: 4211 |
| Zhu J, Ke K, Xu L, et al. (2019) Theoretical studies on the selectivity mechanisms of PI3Kδ inhibition with marketed idelalisib and its derivatives by 3D-QSAR, molecular docking, and molecular dynamics simulation. Journal of Molecular Modeling. 25: 242 |
| Li K, Zhu J, Xu L, et al. (2019) Rational Design of Novel Phosphoinositide 3-kinase Gamma (PI3Kγ) Selective Inhibitors: A Computational Investigation Integrating 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation. Chemistry & Biodiversity |
| Shen C, Liu H, Wang X, et al. (2019) Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I NIK Inhibitors. Frontiers in Pharmacology. 10: 345 |
| Zhao Y, Cao J, Melamed A, et al. (2019) Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America |
| Chen J, Landegger LD, Sun Y, et al. (2019) A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nature Protocols |
| Zhu J, Li K, Xu L, et al. (2018) Insight into the Selective Mechanism of PI3Kγ with Benzothiazole and Thiazolopiperidine γ-specific Inhibitors by in Silico Approaches. Chemical Biology & Drug Design |
| Kong X, Sun H, Pan P, et al. (2018) Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK. Physical Chemistry Chemical Physics : Pccp |
| Kloepper J, Riedemann L, Amoozgar Z, et al. (2016) Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proceedings of the National Academy of Sciences of the United States of America |
| Peterson TE, Kirkpatrick ND, Huang Y, et al. (2016) Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proceedings of the National Academy of Sciences of the United States of America |