Alan C. Sartorelli
Affiliations: | Yale University, New Haven, CT |
Area:
Pharmacology, Oncology, Molecular Biology, Cell BiologyGoogle:
"Alan Sartorelli"Children
Sign in to add trainee| Helen A. Seow | grad student | 2002 | Yale |
| Kevin P Rice | post-doc | 2004 | Yale |
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Publications
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| Whicker ME, Lin ZP, Hanna R, et al. (2016) MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. Bmc Cancer. 16: 550 |
| Shyam K, Penketh PG, Baumann RP, et al. (2015) Antitumor sulfonylhydrazines: Design, structure-activity relationships, resistance mechanisms, and strategies for improving therapeutic utility Journal of Medicinal Chemistry. 58: 3639-3671 |
| Ishiguro K, Lin ZP, Penketh PG, et al. (2014) Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochemical Pharmacology. 91: 312-22 |
| Penketh PG, Patridge E, Shyam K, et al. (2014) Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine. Chemical Research in Toxicology. 27: 1440-9 |
| Penketh PG, Shyam K, Zhu R, et al. (2014) Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W. Chemical Research in Toxicology. 27: 818-33 |
| Lin ZP, Ratner ES, Whicker ME, et al. (2014) Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. Molecular Cancer Research : McR. 12: 381-93 |
| Lamb KL, Liu Y, Ishiguro K, et al. (2014) Tumor-associated mutations in O6-methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality Molecular Carcinogenesis. 53: 201-210 |
| Ishiguro K, Shyam K, Penketh PG, et al. (2013) Expression of O (6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue. Journal of Cancer Therapy. 4: 919-931 |
| Zhu R, Baumann RP, Patridge E, et al. (2013) Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Bioorganic & Medicinal Chemistry Letters. 23: 1853-9 |
| Zhu R, Baumann RP, Penketh PG, et al. (2013) Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine. Journal of Medicinal Chemistry. 56: 1355-9 |