Ann E. Eakin
Affiliations: | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Pharmacy, Molecular BiologyGoogle:
"Ann Eakin"
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Publications
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| Basarab GS, Manchester JI, Bist S, et al. (2013) Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. Journal of Medicinal Chemistry. 56: 8712-35 |
| Mills SD, Eakin AE, Buurman ET, et al. (2011) Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo. Antimicrobial Agents and Chemotherapy. 55: 1088-96 |
| Craig SP, Eakin AE. (2005) Purine salvage enzymes of parasites as targets for structure-based inhibitor design. Parasitology Today (Personal Ed.). 13: 238-41 |
| Wenck MA, Medrano FJ, Eakin AE, et al. (2004) Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi. Biochimica Et Biophysica Acta. 1700: 11-8 |
| Butterworth AC, Medrano FJ, Eakin AE, et al. (2004) Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi. Biochimica Et Biophysica Acta. 1699: 87-94 |
| Canyuk B, Medrano FJ, Wenck MA, et al. (2004) Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase. Journal of Molecular Biology. 335: 905-21 |
| Medrano FJ, Wenck MA, Eakin AE, et al. (2003) Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase. Biochimica Et Biophysica Acta. 1650: 105-16 |
| Barnes BJ, Izydore RA, Eakin AE, et al. (2001) Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: potent inhibitors of human type II inosine 5'-monophosphate dehydrogenase. International Journal of Cancer. Journal International Du Cancer. 94: 275-81 |
| Lee CC, Medrano FJ, Craig SP, et al. (2001) Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase. Biochimica Et Biophysica Acta. 1537: 63-70 |
| Barnes BJ, Eakin AE, Izydore RA, et al. (2001) Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death. Biochemical Pharmacology. 62: 91-100 |