Karen M. Spach, Ph.D.

Affiliations: 
2005 University of Wisconsin, Madison, Madison, WI 
Area:
Nutrition, Immunology
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"Karen Spach"

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Colleen E. Hayes grad student 2005 UW Madison
 (The vitamin D endocrine system in the control of experimental autoimmune encephalomyelitis.)
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Publications

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Noubade R, Krementsov DN, Del Rio R, et al. (2011) Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood. 118: 3290-300
Spach KM, Case LK, Noubade R, et al. (2010) Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice. Genes and Immunity. 11: 649-59
Nashold FE, Spach KM, Spanier JA, et al. (2009) Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression Journal of Immunology. 183: 3672-3681
Spach KM, Noubade R, McElvany B, et al. (2009) A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 182: 7776-83
Spach KM, Blake M, Bunn JY, et al. (2009) Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 1789-93
Pedersen LB, Nashold FE, Spach KM, et al. (2007) 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking. Journal of Neuroscience Research. 85: 2480-90
Spach KM, Nashold FE, Dittel BN, et al. (2006) IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 6030-7
Teuscher C, Noubade R, Spach K, et al. (2006) Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 8024-9
Spach KM, Hayes CE. (2005) Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice. Journal of Immunology (Baltimore, Md. : 1950). 175: 4119-26
Spach KM, Pedersen LB, Nashold FE, et al. (2004) Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis. Physiological Genomics. 18: 141-51
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