Cynthia R. Shirley, Ph.D.

Affiliations: 
2003 The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Cell Biology
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"Cynthia Shirley"

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Marvin Meistrich grad student 2003 The University of Texas Graduate School of Biomedical Sciences at Houston
 (Importance of sperm transition proteins demonstrated in mice carrying Tnp1- and Tnp2-null alleles.)
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Publications

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Al-Shami A, Jhaver KG, Vogel P, et al. (2010) Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. Plos One. 5: e13654
Perl A, Qian Y, Chohan KR, et al. (2006) Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 103: 14813-8
Torregrosa N, Domínguez-Fandos D, Camejo MI, et al. (2006) Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients. Human Reproduction (Oxford, England). 21: 2084-9
Shirley CR, Hayashi S, Mounsey S, et al. (2004) Abnormalities and reduced reproductive potential of sperm from Tnp1- and Tnp2-null double mutant mice. Biology of Reproduction. 71: 1220-9
Zhao M, Shirley CR, Mounsey S, et al. (2004) Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations. Biology of Reproduction. 71: 1016-25
Zhao M, Shirley CR, Hayashi S, et al. (2004) Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis (New York, N.Y. : 2000). 38: 200-13
Meistrich ML, Mohapatra B, Shirley CR, et al. (2003) Roles of transition nuclear proteins in spermiogenesis. Chromosoma. 111: 483-8
Zhao M, Shirley CR, Yu YE, et al. (2001) Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Molecular and Cellular Biology. 21: 7243-55
Yu YE, Zhang Y, Unni E, et al. (2000) Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 4683-8
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