Aaron R. Osborne, Ph.D.
Affiliations: | 2001 | University of South Florida, Tampa, FL, United States |
Area:
Molecular Biology, OncologyGoogle:
"Aaron Osborne"Parents
Sign in to add mentor| George Blanck | grad student | 2001 | University of South Florida | |
| (Histone deacetylase -mediated repression of HLA -DRA promoter chromatin RB -defective tumor cells.) | ||||
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Publications
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| Niesen MI, Osborne AR, Lagor WR, et al. (2009) Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX. Acta Biochimica Et Biophysica Sinica. 41: 198-205 |
| Palubin KM, Goodwin BL, Niesen MI, et al. (2006) A direct mechanistic link between growth control and a tumor cell immune function: increased interleukin-8 secretion accounts for elimination of Oct-1 antisense transformants from scid mice. Anticancer Research. 26: 1733-8 |
| Osborne AR, Zhang H, Blanck G. (2006) Oct-1 DNA binding activity unresponsive to retinoblastoma protein expression prevents MHC class II induction in a non-small cell lung carcinoma cell line. Molecular Immunology. 43: 710-6 |
| Niesen MI, Osborne AR, Yang H, et al. (2005) Activation of a methylated promoter mediated by a sequence-specific DNA-binding protein, RFX. The Journal of Biological Chemistry. 280: 38914-22 |
| Osborne AR, Zhang H, Fejer G, et al. (2004) Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. The Journal of Biological Chemistry. 279: 28911-9 |
| Osborne A, Zhang H, Yang W, et al. (2001) Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase, I-hypersensitive chromatin conformation Molecular and Cellular Biology. 21: 6495-6506 |
| Osborne A, Tschickardt M, Blanck G. (1998) Retinoblastoma protein expression facilitates chromatin remodeling at the HLA-DRA promoter. Nucleic Acids Research. 25: 5095-102 |