Tracy C. Vargo-Gogola, Ph.D.

Affiliations: 
2002 Vanderbilt University, Nashville, TN 
Area:
Cell Biology, Oncology
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"Tracy Vargo-Gogola"

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Lynn M. Matrisian grad student 2002 Vanderbilt
 (The mechanisms by which matrix metalloproteinase-7 promotes mammary tumorigenesis.)
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Bray K, Gillette M, Young J, et al. (2013) Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Research : Bcr. 15: R91
Gillette M, Bray K, Blumenthaler A, et al. (2013) P190B RhoGAP overexpression in the developing mammary epithelium induces TGFβ-dependent fibroblast activation. Plos One. 8: e65105
Hwang M, Peddibhotla S, McHenry P, et al. (2012) P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells. Cancers. 4: 475-89
Gillette M, McHenry P, Blumenthaler A, et al. (2012) Abstract 32: P190B RhoGAP overexpression drives mammary epithelial cell proliferation by altering stromal-epithelial interactions in the developing mammary gland Cancer Research. 72: 32-32
Bray K, Brakebusch C, Vargo-Gogola T. (2011) The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro. Small Gtpases. 2: 247-258
Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, et al. (2011) P190A RhoGAP is required for mammary gland development. Developmental Biology. 360: 1-10
McHenry PR, Sears JC, Herrick MP, et al. (2010) P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Research : Bcr. 12: R73
Lynch CC, Vargo-Gogola T, Matrisian LM, et al. (2010) Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA. Journal of Oncology. 2010: 530745
Vargo-Gogola T. (2010) Putting the brakes on breast cancer: therapeutic opportunities to bring cancer stem cells and the tumor microenvironment to a screeching halt. Current Drug Targets. 11: 1041-1042
McHenry PR, Vargo-Gogola T. (2010) Pleiotropic Functions of Rho GTPase Signaling: a Trojan Horse or Achilles’ Heel for Breast Cancer Treatment? Current Drug Targets. 11: 1043-1058
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