Shaila Rahman, Ph.D.

Affiliations: 
2012 Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Area:
Virology Biology, Molecular Biology
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"Shaila Rahman"

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Peter M. Howley grad student 2012 Harvard
 (Molecular insight into function of the evolutionarily conserved Brd4 extraterminal domain (ET) and mechanism of Brd4 functions in human diseases.)
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Publications

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French CA, Rahman S, Walsh EM, et al. (2014) NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discovery. 4: 928-41
Walsh E, Kuhnle S, Rahman S, et al. (2014) Abstract 2476: A novel NUT translocation partner binds to BRD4 and is necessary for the blockade of differentiation in NUT midline carcinoma Cancer Research. 74: 2476-2476
Rahman S, Sowa ME, Ottinger M, et al. (2011) The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Molecular and Cellular Biology. 31: 2641-52
Botbol Y, Raghavendra NK, Rahman S, et al. (2008) Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro. Nucleic Acids Research. 36: 1237-46
Rahman S, Lu R, Vandegraaff N, et al. (2007) Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology. 357: 79-90
Turlure F, Maertens G, Rahman S, et al. (2006) A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic Acids Research. 34: 1653-65
Cherepanov P, Ambrosio AL, Rahman S, et al. (2005) Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proceedings of the National Academy of Sciences of the United States of America. 102: 17308-13
Cherepanov P, Sun ZY, Rahman S, et al. (2005) Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nature Structural & Molecular Biology. 12: 526-32
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