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Dedra H. Fagan, Ph.D.

Affiliations: 
2012 Pharmacology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Oncology, Molecular Biology
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"Dedra Fagan"
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Douglas Yee grad student 2012 UMN
 (Examination of molecular changes in acquired tamoxifen resistance and subsequent response to anti-IGF1R therapy.)

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Fagan DH, Fettig LM, Avdulov S, et al. (2017) Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation. Hormones & Cancer
Becker MA, Ibrahim YH, Oh AS, et al. (2016) Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer. Plos One. 11: e0150564
Walter W, Thomalla J, Bruhn J, et al. (2015) Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells. Springerplus. 4: 689
Yang Y, Fagan D, Anderson LF, et al. (2013) Abstract IA17: Targeting downstream effectors of growth factor signaling Molecular Cancer Research. 11
Fagan DH, Uselman RR, Sachdev D, et al. (2012) Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment. Cancer Research. 72: 3372-80
Fagan DH, Uselman RR, Sachdev D, et al. (2012) Expression of type I insulin-like growth factor receptor (IGF1R) in tamoxifen-resistant cells: Implications for cotargeting of IGF1R and estrogen receptor (ER) in breast cancer. Journal of Clinical Oncology. 30: e13590-e13590
Zhang H, Fagan DH, Zeng X, et al. (2010) Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 29: 2517-27
Yee D, Fagan DH, Zhang X, et al. (2009) Abstract CN07-02: Disrupting insulin‐like growth factor signaling with monoclonal antibodies Molecular Cancer Therapeutics. 8
Yee D, Zhang X, LaPara K, et al. (2009) 58 Inhibition of IGF signalling as cancer therapy European Journal of Cancer Supplements. 7: 17
Fagan DH, Yee D. (2008) Crosstalk between IGF1R and estrogen receptor signaling in breast cancer. Journal of Mammary Gland Biology and Neoplasia. 13: 423-9
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