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Jack P. Uetrecht

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Toxicology, Pharmacology, Molecular Biology
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"Jack Uetrecht"
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Weidong G. Lai grad student 2000 University of Toronto
Ebrahim Sayeh grad student 2001 University of Toronto
Suzanne L. Iverson grad student 2002 University of Toronto
Xiaochu Zhang grad student 2012 University of Toronto
Ervin X. Zhu grad student 2012 University of Toronto
Alexandra R. Lobach grad student 2014 University of Toronto

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Publications

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Jee A, Christine Sernoskie S, Uetrecht J. (2024) The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology
Sernoskie SC, Bonneil É, Thibault P, et al. (2024) . The Journal of Pharmacology and Experimental Therapeutics
Cho T, Wierk A, Gertsenstein M, et al. (2024) The development and characterization of a CRISPR/Cas9-mediated PD-1 functional knockout rat as a tool to study idiosyncratic drug reactions. Toxicological Sciences : An Official Journal of the Society of Toxicology
Sernoskie SC, Jee A, Uetrecht J. (2023) The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis. International Journal of Molecular Sciences. 24
Uetrecht J. (2022) Idiosyncratic Drug Reactions: A 35-Year Perspective. Chemical Research in Toxicology
Sernoskie SC, Lobach AR, Kato R, et al. (2022) Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 186: 70-82
Sernoskie SC, Jee A, Uetrecht JP. (2021) The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions. Pharmacological Reviews. 73: 861-896
Teschke R, Uetrecht J. (2021) Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. Annals of Translational Medicine. 9: 730
Jee A, Sernoskie SC, Uetrecht J. (2021) Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges. International Journal of Molecular Sciences. 22
Cho T, Kok LY, Uetrecht J. (2021) Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d-Tryptophan or Acetaminophen. Acs Omega. 6: 4656-4662
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