Gregg L. Semenza
Affiliations: | Johns Hopkins University, Baltimore, MD |
Area:
Cell Biology, Molecular BiologyWebsite:
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0800056/gregg-semenzaGoogle:
"Gregg L. Semenza"Bio:
The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability"
http://www.nasonline.org/member-directory/members/20017183.html
https://hub.jhu.edu/2019/10/07/gregg-semenza-nobel-prize-physiology-medicine/
https://doi.org/10.1073/pnas.1009481107
DOI: 10.1073/pnas.1617222113
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Elias Schwartz | grad student | 1984 | Penn | |
| (Molecular genetic analysis of the silent carrier of β thalassemia.) | ||||
| Saul Surrey | grad student | 1984 | Penn | |
| Stylianos Antonarakis | post-doc | 1986-1989 | Johns Hopkins Medical School | |
| Haig H. Kazazian | post-doc | 1986-1989 | Johns Hopkins Medical School | |
Children
Sign in to add trainee| Maimon E. Hubbi | grad student | 2010 | Johns Hopkins |
| Luana Schito | grad student | 2008-2011 | Johns Hopkins |
| Daniele M. Gilkes | post-doc | Johns Hopkins | |
| Weibo Luo | post-doc | UT Southwestern | |
| Marta Bosch-Marce | post-doc | 2005-2008 | Johns Hopkins |
| Sergio Rey | post-doc | 2007-2011 | |
| Daniele M Gilkes | post-doc | 2009-2014 | |
| Emmanuel Datan | research scientist | 2020- | Johns Hopkins University - Genetic Medicine/Cell Engineering (Chemistry Tree) |
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Publications
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| Lyu Y, Yang Y, Talwar V, et al. (2024) Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. Cell Reports. 43: 113972 |
| Gilkes DM, Bajpai S, Wong CC, et al. (2023) Retraction: Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis. Molecular Cancer Research : McR. 21: 1120 |
| Semenza GL. (2023) Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1. Stem Cells Translational Medicine |
| Semenza GL. (2023) Targeting intratumoral hypoxia to enhance anti-tumor immunity. Seminars in Cancer Biology. 96: 5-10 |
| Gilkes DM, Bajpai S, Chaturvedi P, et al. (2023) Withdrawal: Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 299: 105144 |
| Zhang H, Bosch-Marce M, Shimoda LA, et al. (2023) Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 299: 105125 |
| Zuo Q, Yang Y, Lyu Y, et al. (2023) Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Reports. 42: 112164 |
| Yang Y, Chen C, Zuo Q, et al. (2022) NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Science Advances. 8: eabo5000 |
| Poll SR, Martin R, Wohler E, et al. (2022) Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome. Plos Genetics. 18: e1010504 |
| Koyasu S, Horita S, Saito K, et al. (2022) ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Embo Reports. e202154042 |