Thomas J. Begley

Affiliations: 
Biomedical Sciences State University of New York, Albany, Albany, NY, United States 
Area:
Molecular Biology, Cell Biology, Genetics, Oncology
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"Thomas Begley"
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Publications

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Mitchener MM, Begley TJ, Dedon PC. (2023) Molecular Coping Mechanisms: Reprogramming tRNAs To Regulate Codon-Biased Translation of Stress Response Proteins. Accounts of Chemical Research. 56: 3504-3514
Dedon PC, Begley TJ. (2022) Dysfunctional tRNA reprogramming and codon-biased translation in cancer. Trends in Molecular Medicine. 28: 964-978
Huber SM, Begley U, Sarkar A, et al. (2022) Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123529119
Evke S, Lin Q, Melendez JA, et al. (2022) Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen. Genes. 13
St John N, Freedland J, Baldino H, et al. (2020) Genome Profiling for Aflatoxin B Resistance in Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B-Associated DNA Damage. G3 (Bethesda, Md.)
Leonardi A, Kovalchuk N, Yin L, et al. (2020) The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene. Epigenetics. 1-18
Pollo-Oliveira L, Klassen R, Davis N, et al. (2020) Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast. Biomolecules. 10
Lee MY, Leonardi A, Begley TJ, et al. (2019) Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming. Redox Biology. 28: 101375
Leonardi A, Evke S, Lee M, et al. (2019) Epitranscriptomic systems regulate the translation of reactive oxygen species detoxifying and disease linked selenoproteins. Free Radical Biology & Medicine
Huber SM, Leonardi A, Dedon PC, et al. (2019) The Versatile Roles of the tRNA Epitranscriptome during Cellular Responses to Toxic Exposures and Environmental Stress. Toxics. 7
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