Gordon Kirby
Affiliations: | University of Guelph (Canada), Guelph, Ontario, Canada |
Area:
Toxicology, Molecular BiologyGoogle:
"Gordon Kirby"
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Publications
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| Morgan L, Antenos M, Kirby GM. (2022) Nrf2-mediated induction of Cyp2a5 partially protects against reductive endoplasmic reticulum stress in mouse hepatocytes. Toxicology. 471: 153162 |
| Kim SD, Morgan L, Hargreaves E, et al. (2021) Regulation of Cytochrome P450 2a5 by and 6,7-Dimethylesculetin in Mouse Hepatocytes. Frontiers in Pharmacology. 12: 730416 |
| Jiang Z, Guo X, Zhang K, et al. (2019) The Essential Oils and Eucalyptol From L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2-Keap1 and Enhancing APAP Clearance Through Non-Toxic Metabolic Pathway. Frontiers in Pharmacology. 10: 782 |
| Kim SD, Antenos M, Squires EJ, et al. (2013) Cytochrome P450 2A5 and bilirubin: mechanisms of gene regulation and cytoprotection. Toxicology and Applied Pharmacology. 270: 129-38 |
| Kirby GM, Nichols KD, Antenos M. (2011) CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis. Current Drug Metabolism. 12: 186-97 |
| Nichols KD, Kirby GM. (2008) Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochemical Pharmacology. 75: 1230-9 |
| Onica T, Nichols K, Larin M, et al. (2008) Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Molecular Pharmacology. 73: 451-60 |
| Nichols KD, Kirby GM. (2008) Microarray analysis of hepatic gene expression in pyrazole-mediated hepatotoxicity: identification of potential stimuli of Cyp2a5 induction. Biochemical Pharmacology. 75: 538-51 |
| Romero L, Andrews K, Ng L, et al. (2006) Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cells Biochemical Journal. 400: 135-141 |
| Romero L, Ng L, Kirby GM. (2006) Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C. Molecular Pharmacology. 70: 277-86 |