Jason M. Spaeth, Ph.D.
Affiliations: | 2012 | Molecular Medicine | The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States |
Area:
Molecular BiologyGoogle:
"Jason Spaeth"Parents
Sign in to add mentor| Thomas G. Boyer | grad student | 2012 | UT Health San Antonio | |
| (Molecular determinants and pathological disruption of a MED12-Cyclin C interface in mediator.) | ||||
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Publications
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| Davidson RK, Weaver SA, Casey N, et al. (2022) The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function. Journal of Molecular Endocrinology |
| Simonett SP, Shin S, Herring JA, et al. (2021) Identification of direct transcriptional targets of NFATC2 that promote β-cell proliferation. The Journal of Clinical Investigation |
| Davidson RK, Kanojia S, Spaeth JM. (2020) The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity. Endocrinology |
| Davidson RK, Casey N, Spaeth J. (2020) 2049-P: The Chd4 Helicase of the Nucleosome Remodeling and Deacetylase Complex Modulates Pdx1 Target Gene Expression In Vitro Diabetes. 69 |
| Spaeth JM, Liu JH, Peters D, et al. (2019) The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes |
| Wilson CS, Spaeth JM, Karp J, et al. (2019) B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib. Jci Insight. 5 |
| Russell MA, Redick SD, Blodgett DM, et al. (2019) HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet β-Cells from Donors with Type 1 Diabetes. Diabetes |
| Park MJ, Shen H, Spaeth JM, et al. (2018) Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of Cyclin C-CDK8/19. The Journal of Biological Chemistry |
| Spaeth JM, Gupte M, Perelis M, et al. (2017) Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Diabetes |
| Dean ED, Li M, Prasad N, et al. (2017) Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell Metabolism. 25: 1362-1373.e5 |