Andrew A. Horwitz, Ph.D.
Affiliations: | 2006 | Harvard University, Cambridge, MA, United States |
Area:
Molecular Biology, Cell BiologyGoogle:
"Andrew Horwitz"Parents
Sign in to add mentor| Jeffrey Parvin | grad student | 2006 | Harvard | |
| (Regulation of RNA polymerase II by BRCA1, the breast cancer tumor suppressor.) | ||||
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Publications
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| Horwitz AA, Walter JM, Schubert MG, et al. (2015) Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas. Cell Systems. 1: 88-96 |
| Moser F, Horwitz A, Chen J, et al. (2013) Genetic sensor for strong methylating compounds. Acs Synthetic Biology. 2: 614-24 |
| Hammond-Martel I, Pak H, Yu H, et al. (2010) PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells. Plos One. 5: e14027 |
| Lamber EP, Horwitz AA, Parvin JD. (2010) BRCA1 represses amphiregulin gene expression. Cancer Research. 70: 996-1005 |
| Heine GF, Horwitz AA, Parvin JD. (2008) Multiple mechanisms contribute to inhibit transcription in response to DNA damage. The Journal of Biological Chemistry. 283: 9555-61 |
| Horwitz AA, Navon A, Groll M, et al. (2007) ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea. The Journal of Biological Chemistry. 282: 22921-9 |
| Horwitz AA, Affar el B, Heine GF, et al. (2007) A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 104: 6614-9 |
| Simons AM, Horwitz AA, Starita LM, et al. (2006) BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Research. 66: 2012-8 |
| Horwitz AA, Sankaran S, Parvin JD. (2006) Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini. The Journal of Biological Chemistry. 281: 8317-20 |
| Starita LM, Horwitz AA, Keogh MC, et al. (2005) BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. The Journal of Biological Chemistry. 280: 24498-505 |