Mark Spear, Ph.D.
Affiliations: | 2014 | Biosciences | George Mason University, Washington, DC |
Area:
Virology Biology, Immunology, Molecular BiologyGoogle:
"Mark Spear"Parents
Sign in to add mentor| Yuntao Wu | grad student | 2014 | George Mason | |
| (The Elucidation of the Role of Arp2/3 in HIV-1 Replication in CD4 T Cells.) | ||||
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Publications
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| Hetrick B, Siddiqui S, Spear M, et al. (2024) Suppression of viral rebound by a Rev-dependent lentiviral particle in SIV-infected rhesus macaques. Gene Therapy |
| He S, Guo J, Fu Y, et al. (2021) Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells. Iscience. 24: 103305 |
| He S, Fu Y, Guo J, et al. (2019) Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-αβ integrin antibody. Science Advances. 5: eaat7911 |
| Yi F, Guo J, Dabbagh D, et al. (2017) Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. Journal of Virology |
| Spear M, Wu Y. (2014) Viral exploitation of actin: force-generation and scaffolding functions in viral infection. Virologica Sinica. 29: 139-47 |
| Spear M, Guo J, Turner A, et al. (2014) HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. The Journal of Biological Chemistry. 289: 6949-59 |
| Spear M, Guo J, Wu Y. (2013) Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways. Immunological Reviews. 256: 300-12 |
| Hawley T, Spear M, Guo J, et al. (2013) Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents. Cell & Bioscience. 3: 22 |
| Spear M, Guo J, Wu Y. (2012) The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology. 9: 45 |
| Vorster PJ, Guo J, Yoder A, et al. (2011) LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection. The Journal of Biological Chemistry. 286: 12554-64 |