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Sichang Zhou, Ph.D.

Affiliations: 
2011 Physiology Wayne State University, Detroit, MI, United States 
Area:
Physiology Biology
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"Sichang Zhou"
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Daniel A. Rappolee grad student 2011 Wayne State
 (Cell lineage choice during differentiation of trophoblast stem cells (TSC) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function.)

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Publications

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Bolnick A, Awonuga AO, Yang Y, et al. (2017) Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress. Journal of Assisted Reproduction and Genetics
Xie Y, Zhou S, Jiang Z, et al. (2014) Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency. Stem Cell Research. 13: 478-91
Slater JA, Zhou S, Puscheck EE, et al. (2014) Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineage. Stem Cells and Development. 23: 3049-64
Rappolee DA, Zhou S, Puscheck EE, et al. (2013) Stress responses at the endometrial-placental interface regulate labyrinthine placental differentiation from trophoblast stem cells. Reproduction (Cambridge, England). 145: R139-55
Rappolee D, Jiang Z, Zhou S, et al. (2013) Stress induces placental differentiation from stem cells that is different in seven ways compared with normal differentiation Placenta. 34: A91
Puscheck E, Jiang Z, Xie Y, et al. (2013) SAPK activity is a better marker than AMPK activity for measuring stressful O2 levels in stem cells Fertility and Sterility. 100: S456
Rappolee DA, Xie Y, Slater JA, et al. (2012) Toxic stress prioritizes and imbalances stem cell differentiation: implications for new biomarkers and in vitro toxicology tests. Systems Biology in Reproductive Medicine. 58: 33-40
Awonuga AO, Zhong W, Abdallah ME, et al. (2011) Eomesodermin, HAND1, and CSH1 proteins are induced by cellular stress in a stress-activated protein kinase-dependent manner. Molecular Reproduction and Development. 78: 519-28
Zhou S, Xie Y, Puscheck EE, et al. (2011) Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress. Placenta. 32: 475-81
Xie Y, Awonuga AO, Zhou S, et al. (2011) Interpreting the stress response of early mammalian embryos and their stem cells. International Review of Cell and Molecular Biology. 287: 43-95
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