Sam R. Holmstrom, Ph.D.

Affiliations: 
2006 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacology, Molecular Biology
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"Sam Holmstrom"

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Jorge Iniguez-Lluhi grad student 2006 University of Michigan
 (Probing the mechanisms of synergy control motifs in the glucocorticoid receptor: A role for posttranslational modification by the small ubiquitin -like modifier (SUMO).)
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Publications

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Wijayatunge R, Holmstrom SR, Foley SB, et al. (2018) Deficiency of the Endocytic Protein Leads to Decreased expression, Low Phosphocholine, and Kypholordosis. Molecular and Cellular Biology
Holmstrom SR, Deering T, Swift GH, et al. (2011) LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes & Development. 25: 1674-9
Li T, Holmstrom SR, Kir S, et al. (2011) The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molecular Endocrinology (Baltimore, Md.). 25: 1066-71
Schmidt DR, Schmidt S, Holmstrom SR, et al. (2011) AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. The Journal of Biological Chemistry. 286: 2425-32
Schmidt DR, Holmstrom SR, Fon Tacer K, et al. (2010) Regulation of bile acid synthesis by fat-soluble vitamins A and D. The Journal of Biological Chemistry. 285: 14486-94
Holmstrom SR, Chupreta S, So AY, et al. (2008) SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX. Molecular Endocrinology (Baltimore, Md.). 22: 2061-75
Choi M, Moschetta A, Bookout AL, et al. (2006) Identification of a hormonal basis for gallbladder filling. Nature Medicine. 12: 1253-5
Chupreta S, Holmstrom S, Subramanian L, et al. (2005) A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Molecular and Cellular Biology. 25: 4272-82
Holmstrom S, Van Antwerp ME, Iñiguez-Lluhi JA. (2003) Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proceedings of the National Academy of Sciences of the United States of America. 100: 15758-63
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