Akio Ohta

Affiliations: 
Biology Northeastern University, Boston, MA, United States 
Area:
General Biology, Immunology, Cell Biology
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"Akio Ohta"
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Publications

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Ohta A. (2019) Oxygen-dependent regulation of immune checkpoint mechanisms. International Immunology. 30: 335-343
Kjaergaard J, Hatfield S, Jones G, et al. (2018) A Adenosine Receptor Gene Deletion or Synthetic A Antagonist Liberate Tumor-Reactive CD8 T Cells from Tumor-Induced Immunosuppression. Journal of Immunology (Baltimore, Md. : 1950)
Sethumadhavan S, Silva M, Philbrook P, et al. (2017) Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. Plos One. 12: e0187314
Abbott RK, Silva M, Labuda J, et al. (2016) The GS protein coupled A2a adenosine receptor controls T cell help in the germinal center. The Journal of Biological Chemistry
Abbott RK, Thayer M, Labuda J, et al. (2016) Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. Journal of Immunology (Baltimore, Md. : 1950)
Ohta A. (2016) A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment. Frontiers in Immunology. 7: 109
Hatfield SM, Kjaergaard J, Lukashev D, et al. (2015) Immunological mechanisms of the antitumor effects of supplemental oxygenation. Science Translational Medicine. 7: 277ra30
Hatfield SM, Kjaergaard J, Lukashev D, et al. (2014) Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection. Journal of Molecular Medicine (Berlin, Germany). 92: 1283-92
Ohta A, Sitkovsky M. (2014) Extracellular adenosine-mediated modulation of regulatory T cells. Frontiers in Immunology. 5: 304
Sitkovsky MV, Hatfield S, Abbott R, et al. (2014) Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists. Cancer Immunology Research. 2: 598-605
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