Akio Ohta
Affiliations: | Biology | Northeastern University, Boston, MA, United States |
Area:
General Biology, Immunology, Cell BiologyGoogle:
"Akio Ohta"
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Publications
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Ohta A. (2019) Oxygen-dependent regulation of immune checkpoint mechanisms. International Immunology. 30: 335-343 |
Kjaergaard J, Hatfield S, Jones G, et al. (2018) A Adenosine Receptor Gene Deletion or Synthetic A Antagonist Liberate Tumor-Reactive CD8 T Cells from Tumor-Induced Immunosuppression. Journal of Immunology (Baltimore, Md. : 1950) |
Sethumadhavan S, Silva M, Philbrook P, et al. (2017) Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. Plos One. 12: e0187314 |
Abbott RK, Silva M, Labuda J, et al. (2016) The GS protein coupled A2a adenosine receptor controls T cell help in the germinal center. The Journal of Biological Chemistry |
Abbott RK, Thayer M, Labuda J, et al. (2016) Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. Journal of Immunology (Baltimore, Md. : 1950) |
Ohta A. (2016) A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment. Frontiers in Immunology. 7: 109 |
Hatfield SM, Kjaergaard J, Lukashev D, et al. (2015) Immunological mechanisms of the antitumor effects of supplemental oxygenation. Science Translational Medicine. 7: 277ra30 |
Hatfield SM, Kjaergaard J, Lukashev D, et al. (2014) Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection. Journal of Molecular Medicine (Berlin, Germany). 92: 1283-92 |
Ohta A, Sitkovsky M. (2014) Extracellular adenosine-mediated modulation of regulatory T cells. Frontiers in Immunology. 5: 304 |
Sitkovsky MV, Hatfield S, Abbott R, et al. (2014) Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists. Cancer Immunology Research. 2: 598-605 |