Shireen A. Sarraf, Ph.D.

Affiliations: 
2013 Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Area:
Cell Biology, Molecular Biology
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"Shireen Sarraf"

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Wade Harper grad student 2013 Harvard
 (Defining the landscape of the PARKIN- and PINK1-dependent ubiquitin-modified proteome in response to mitochondrial dysfunction.)
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Publications

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Sarraf SA, Shah HV, Kanfer G, et al. (2020) Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Molecular Cell
Fritsch LE, Moore ME, Sarraf SA, et al. (2019) Ubiquitin and Receptor Dependent Mitophagy Pathways and Their Implication in Neurodegeneration. Journal of Molecular Biology
Sarraf SA, Sideris DP, Giagtzoglou N, et al. (2019) PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Reports. 29: 225-235.e5
Sarraf SA, Youle RJ. (2018) Parkin mediates mitophagy during beige-to-white fat conversion. Science Signaling. 11
Yamano K, Wang C, Sarraf SA, et al. (2018) Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife. 7
Kohler LJ, Reed SR, Sarraf SA, et al. (2016) Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. Mbio. 7
Lazarou M, Sliter DA, Kane LA, et al. (2015) The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524: 309-14
Ordureau A, Sarraf SA, Duda DM, et al. (2014) Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Molecular Cell. 56: 360-75
Kane LA, Lazarou M, Fogel AI, et al. (2014) PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205: 143-53
Sarraf SA, Raman M, Guarani-Pereira V, et al. (2013) Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 496: 372-6
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