Shireen A. Sarraf, Ph.D.
Affiliations: | 2013 | Biology: Medical Sciences, Division of | Harvard University, Cambridge, MA, United States |
Area:
Cell Biology, Molecular BiologyGoogle:
"Shireen Sarraf"Parents
Sign in to add mentorWade Harper | grad student | 2013 | Harvard | |
(Defining the landscape of the PARKIN- and PINK1-dependent ubiquitin-modified proteome in response to mitochondrial dysfunction.) |
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Publications
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Sarraf SA, Shah HV, Kanfer G, et al. (2020) Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Molecular Cell |
Fritsch LE, Moore ME, Sarraf SA, et al. (2019) Ubiquitin and Receptor Dependent Mitophagy Pathways and Their Implication in Neurodegeneration. Journal of Molecular Biology |
Sarraf SA, Sideris DP, Giagtzoglou N, et al. (2019) PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Reports. 29: 225-235.e5 |
Sarraf SA, Youle RJ. (2018) Parkin mediates mitophagy during beige-to-white fat conversion. Science Signaling. 11 |
Yamano K, Wang C, Sarraf SA, et al. (2018) Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife. 7 |
Kohler LJ, Reed SR, Sarraf SA, et al. (2016) Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. Mbio. 7 |
Lazarou M, Sliter DA, Kane LA, et al. (2015) The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524: 309-14 |
Ordureau A, Sarraf SA, Duda DM, et al. (2014) Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Molecular Cell. 56: 360-75 |
Kane LA, Lazarou M, Fogel AI, et al. (2014) PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205: 143-53 |
Sarraf SA, Raman M, Guarani-Pereira V, et al. (2013) Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 496: 372-6 |