Deepti Malhotra, Ph.D.

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Environmental Health, Pathology, Molecular Biology
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"Deepti Malhotra"

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Shyam Biswal grad student 2010 Johns Hopkins
 (Nrf2-regulated environmental stress response: A modifier of chronic obstructive pulmonary disease (COPD).)
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Publications

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Malhotra D, Thimmulappa RK, Mercado N, et al. (2014) Retraction: Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. The Journal of Clinical Investigation. 124: 5521
McGrath-Morrow SA, Lauer T, Collaco JM, et al. (2014) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status. Cytokine. 65: 4-9
Acquaah-Mensah GK, Malhotra D, Vulimiri M, et al. (2012) Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease. Plos Computational Biology. 8: e1002597
Sandford AJ, Malhotra D, Boezen HM, et al. (2012) NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. Physiological Genomics. 44: 754-63
Malhotra D, Thimmulappa RK, Mercado N, et al. (2011) Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. The Journal of Clinical Investigation. 121: 4289-302
McGrath-Morrow S, Malhotra D, Lauer T, et al. (2011) Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice. Experimental Lung Research. 37: 354-63
Malhotra D, Portales-Casamar E, Singh A, et al. (2010) Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research. 38: 5718-34
Blake DJ, Singh A, Kombairaju P, et al. (2010) Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. American Journal of Respiratory Cell and Molecular Biology. 42: 524-36
Malhotra D, Thimmulappa R, Vij N, et al. (2009) Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. American Journal of Respiratory and Critical Care Medicine. 180: 1196-207
Sussan TE, Rangasamy T, Blake DJ, et al. (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5
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