Markus A. Seeliger

Affiliations: 
Molecular and Cellular Pharmacology Stony Brook University, Stony Brook, NY, United States 
Area:
Pharmacy, Molecular Biology
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"Markus Seeliger"

Parents

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Alan Roy Fersht grad student (Chemistry Tree)
John Kuriyan post-doc UC Berkeley (Chemistry Tree)
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Publications

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Singh S, Gapsys V, Aldeghi M, et al. (2025) Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding. Biorxiv : the Preprint Server For Biology
Singh S, Gapsys V, Aldeghi M, et al. (2025) Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding. The Journal of Physical Chemistry. B
Leyte-Vidal A, DeFilippis R, Outhwaite IR, et al. (2024) Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia
Gebauer E, Seeliger MA. (2024) All the mutations that are fit to die. Cell Chemical Biology. 31: 192-194
Lee JY, Gebauer E, Seeliger MA, et al. (2024) Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments. Current Opinion in Structural Biology. 84: 102770
Outhwaite IR, Singh S, Berger BT, et al. (2023) Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. Elife. 12
Outhwaite IR, Seeliger MA. (2023) Probing conformational dynamics to understand kinase inhibition. Elife. 12
Ayaz P, Lyczek A, Paung Y, et al. (2023) Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885
Kan Y, Paung Y, Seeliger MA, et al. (2023) Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Cells. 12
Kan Y, Paung Y, Kim Y, et al. (2023) Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry
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