Markus A. Seeliger
Affiliations: | Molecular and Cellular Pharmacology | Stony Brook University, Stony Brook, NY, United States |
Area:
Pharmacy, Molecular BiologyGoogle:
"Markus Seeliger"Parents
Sign in to add mentorAlan Roy Fersht | grad student | (Chemistry Tree) | |
John Kuriyan | post-doc | UC Berkeley (Chemistry Tree) |
Children
Sign in to add traineeGeorge Georghiou | grad student | 2014 | SUNY Stony Brook |
Sukrit Singh | post-doc | Stony Brook University Medical Center (Chemistry Tree) |
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Publications
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Singh S, Gapsys V, Aldeghi M, et al. (2025) Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding. Biorxiv : the Preprint Server For Biology |
Singh S, Gapsys V, Aldeghi M, et al. (2025) Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding. The Journal of Physical Chemistry. B |
Leyte-Vidal A, DeFilippis R, Outhwaite IR, et al. (2024) Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia |
Gebauer E, Seeliger MA. (2024) All the mutations that are fit to die. Cell Chemical Biology. 31: 192-194 |
Lee JY, Gebauer E, Seeliger MA, et al. (2024) Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments. Current Opinion in Structural Biology. 84: 102770 |
Outhwaite IR, Singh S, Berger BT, et al. (2023) Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. Elife. 12 |
Outhwaite IR, Seeliger MA. (2023) Probing conformational dynamics to understand kinase inhibition. Elife. 12 |
Ayaz P, Lyczek A, Paung Y, et al. (2023) Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885 |
Kan Y, Paung Y, Seeliger MA, et al. (2023) Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Cells. 12 |
Kan Y, Paung Y, Kim Y, et al. (2023) Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry |