Lawrence Ian Rothblum

Affiliations: 
University of Oklahoma College of Medicine 
Area:
transcription by RNA polymerase I, ribosome biogenesis, regulation of ribosome biogenesis
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"Lawrence Rothblum"
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Publications

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McNamar R, Freeman E, Baylor KN, et al. (2023) PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53. The Journal of Biological Chemistry. 104951
McNamar R, Rothblum K, Rothblum LI. (2021) The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same. Genes. 12
Knutson BA, McNamar R, Rothblum LI. (2020) Dynamics of the RNA polymerase I TFIIF/TFIIE-like subcomplex: a mini-review. Biochemical Society Transactions
McNamar R, Abu-Adas Z, Rothblum K, et al. (2019) Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. The Journal of Biological Chemistry
Rothblum LI, Rothblum K, Chang E. (2016) PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression. Gene
Hung SS, Lesmana A, Peck A, et al. (2016) Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription. Gene
Sanij E, Diesch J, Lesmana A, et al. (2015) A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes. Genome Research. 25: 201-12
Penrod Y, Rothblum K, Cavanaugh A, et al. (2015) Regulation of the association of the PAF53/PAF49 heterodimer with RNA polymerase I. Gene. 556: 61-7
Rothblum K, Hu Q, Penrod Y, et al. (2014) Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3. Molecular Cancer Research : McR. 12: 1586-96
Stepanchick A, Zhi H, Cavanaugh AH, et al. (2013) DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription. The Journal of Biological Chemistry. 288: 9135-44
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