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Sign in to add mentorAlexandra C. Newton | grad student | 2005-2011 | UCSD (Chemistry Tree) | |
(PHLPP Phosphatase Regulation of Growth Factor Signaling.) |
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Publications
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Krall EB, Wang B, Munoz DM, et al. (2017) KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6 |
Crystal AS, Shaw AT, Sequist LV, et al. (2014) Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science (New York, N.Y.). 346: 1480-6 |
Reyes G, Niederst M, Cohen-Katsenelson K, et al. (2014) Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proceedings of the National Academy of Sciences of the United States of America. 111: E3957-65 |
Niederst MJ, Benes CH. (2014) EMT twists the road to PI3K. Cancer Discovery. 4: 149-51 |
Niederst MJ, Engelman JA. (2013) Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer. Science Signaling. 6: re6 |
O'Neill AK, Niederst MJ, Newton AC. (2013) Suppression of survival signalling pathways by the phosphatase PHLPP. The Febs Journal. 280: 572-83 |
O'Hayre M, Niederst M, Fecteau JF, et al. (2012) Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 26: 1689-92 |
Warfel NA, Niederst M, Newton AC. (2011) Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. The Journal of Biological Chemistry. 286: 39122-9 |
Warfel NA, Niederst M, Stevens MW, et al. (2011) Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt Journal of Biological Chemistry. 286: 19777-19788 |
Brognard J, Niederst M, Reyes G, et al. (2009) Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. The Journal of Biological Chemistry. 284: 15215-23 |