Ying Lu, ph.D
Affiliations: | 2000-2004 | Physics | Peking University, China, Beijing, Beijing Shi, China |
2004-2010 | Biophysics | Rockefeller University, New York, NY, United States | |
2010-2016 | Systems Biology | Harvard Medical School, Boston, MA, United States | |
2016- | Systems Biology | Harvard Medical School, Boston, MA, United States |
Area:
Ubiquitin-mediated protein degradationWebsite:
https://yinglu.hms.harvard.edu/researchGoogle:
"Ying Lu"Parents
Sign in to add mentorFrederick Cross | grad student | 2004-2010 | Rockefeller |
Marc W. Kirschner | post-doc | 2010-2016 | Harvard Medical School |
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Publications
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Zhou M, Fang R, Colson L, et al. (2023) HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates. Biorxiv : the Preprint Server For Biology |
Fang R, Hon J, Zhou M, et al. (2022) An empirical energy landscape reveals mechanism of proteasome in polypeptide translocation. Elife. 11 |
Zhao Y, Wang D, Zhang Z, et al. (2020) Critical slowing down and attractive manifold: A mechanism for dynamic robustness in the yeast cell-cycle process. Physical Review. E. 101: 042405 |
Hon J, Lu Y. (2019) Single-molecule methods for measuring ubiquitination and protein stability. Methods in Enzymology. 619: 225-247 |
Dong Y, Zhang S, Wu Z, et al. (2018) Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature |
Zhu Y, Wang WL, Yu D, et al. (2018) Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nature Communications. 9: 1360 |
Lu Y, Wu J, Dong Y, et al. (2017) Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Molecular Cell |
Wan L, Chen M, Cao J, et al. (2017) The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery |
Chen S, Wu J, Lu Y, et al. (2016) Structural basis for dynamic regulation of the human 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America |
Brown NG, VanderLinden R, Watson ER, et al. (2016) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165: 1440-1453 |