Thomas M. Keck
Affiliations: | 2014- | Chemistry & Biochemistry | Rowan University, Glassboro, NJ, United States |
Area:
Pharmacology, medications development, drug addiction, GPCR signalingWebsite:
https://sites.google.com/rowan.edu/kecklabrowan/Google:
"https://scholar.google.com/citations?user=8Dr4c6cAAAAJ&hl=en&authuser=1"Parents
Sign in to add mentor| Seema K. Tiwari-Woodruff | research assistant | 2003-2004 | UC Riverside |
| David K. Grandy | grad student | 2004-2009 | OHSU |
| Amy H. Newman | post-doc | 2009-2014 | NIDA Intramural Research Program (Chemistry Tree) |
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Publications
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| Schweppe CA, Burzynski C, Jayanthi S, et al. (2020) Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms. Psychopharmacology |
| Moritz AE, Free RB, Weiner WS, et al. (2020) Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry |
| Keck TM, Nguyen C, Kurtyan E, et al. (2020) Developing New Dopamine D2 Receptor Agonists and Partial Agonists for Parkinson’s Disease and Schizophrenia The Faseb Journal. 34: 1-1 |
| Moritz AE, Inbody LR, Gandhi DM, et al. (2020) Structure‐Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site The Faseb Journal. 34: 1-1 |
| Keck TM, Free RB, Day MM, et al. (2019) Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy. Journal of Medicinal Chemistry |
| Del Bello F, Ambrosini D, Bonifazi A, et al. (2019) Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia. Acs Chemical Neuroscience |
| Kumar V, Moritz AE, Keck TM, et al. (2017) Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R). Journal of Medicinal Chemistry |
| Michino M, Boateng CA, Donthamsetti P, et al. (2016) Towards understanding the structural basis of partial agonism at the dopamine D3 receptor. Journal of Medicinal Chemistry |
| Del Bello F, Bonifazi A, Giannella M, et al. (2016) The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes. European Journal of Medicinal Chemistry. 125: 233-244 |
| Kumar V, Bonifazi A, Ellenberger MP, et al. (2016) Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. Journal of Medicinal Chemistry |