Roxanne Kay Kunz
Affiliations: | 2003 | University of Michigan, Ann Arbor, Ann Arbor, MI |
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"Roxanne Kunz"Mean distance: 7.84 | S | N | B | C | P |
Parents
Sign in to add mentor| William R. Roush | grad student | 2003 | University of Michigan | |
| (Studies toward the total synthesis of quartromicin D(3).) | ||||
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| Chen H, Lester-Zeiner D, Shi J, et al. (2015) AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer. The Journal of Pharmacology and Experimental Therapeutics. 352: 327-37 |
| Rzasa RM, Frohn MJ, Andrews KL, et al. (2014) Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorganic & Medicinal Chemistry. 22: 6570-85 |
| Hu E, Chen N, Bourbeau MP, et al. (2014) Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 57: 6632-41 |
| Nishimura N, Norman MH, Liu L, et al. (2014) Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. Journal of Medicinal Chemistry. 57: 3094-116 |
| St Jean DJ, Ashton KS, Bartberger MD, et al. (2014) Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. Journal of Medicinal Chemistry. 57: 325-38 |
| Hu E, Kunz RK, Chen N, et al. (2013) Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 56: 8781-92 |
| Hu E, Kunz RK, Rumfelt S, et al. (2012) Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3). Bioorganic & Medicinal Chemistry Letters. 22: 6938-42 |
| Hu E, Ma J, Biorn C, et al. (2012) Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer. Journal of Medicinal Chemistry. 55: 4776-87 |
| Hu E, Kunz RK, Rumfelt S, et al. (2012) Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2262-5 |
| Kunz RK, MacMillan DWC. (2005) Enantioselective organocatalytic cyclopropanations. The identification of a new class of iminium catalyst based upon directed electrostatic activation Journal of the American Chemical Society. 127: 3240-3241 |