Heather Christina Losey
Affiliations: | 2003 | Harvard University, Cambridge, MA, United States |
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"Heather Losey"Mean distance: 7.38 | S | N | B | C | P |
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Sign in to add mentor| Christopher T. Walsh | grad student | 2003 | Harvard | |
| (Glycosyltransferases involved in the biosynthesis of glycopeptide antibiotics.) | ||||
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| Losey HC, Ruthenburg AJ, Verdine GL. (2006) Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Nature Structural & Molecular Biology. 13: 153-9 |
| Mulichak AM, Lu W, Losey HC, et al. (2004) Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry. 43: 5170-80 |
| Walsh C, Freel Meyers CL, Losey HC. (2003) Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming. Journal of Medicinal Chemistry. 46: 3425-36 |
| Mulichak AM, Losey HC, Lu W, et al. (2003) Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 100: 9238-43 |
| Walsh CT, Losey HC, Freel Meyers CL. (2003) Antibiotic glycosyltransferases. Biochemical Society Transactions. 31: 487-92 |
| Losey HC, Jiang J, Biggins JB, et al. (2002) Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chemistry & Biology. 9: 1305-14 |
| Dong SD, Oberthür M, Losey HC, et al. (2002) The structural basis for induction of VanB resistance. Journal of the American Chemical Society. 124: 9064-5 |
| Merkel AB, Temple GK, Burkart MD, et al. (2002) Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway. Acta Crystallographica. Section D, Biological Crystallography. 58: 1226-8 |
| Walsh CT, Chen H, Keating TA, et al. (2001) Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. Current Opinion in Chemical Biology. 5: 525-34 |
| Mulichak AM, Losey HC, Walsh CT, et al. (2001) Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure (London, England : 1993). 9: 547-57 |