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Qinheng Zheng, Ph.D.

Affiliations: 
2010-2014 College of Chemistry and Molecular Engineering Peking University, Beijing, Beijing Shi, China 
 2014-2020 Department of Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2020- Department of Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
Area:
Chemistry
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"Qinheng Zheng"
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Parents

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Zhi-Xiang Yu research assistant 2012-2014 Peking University
K. Barry Sharpless grad student 2014- Scripps Institute
Kevan Michael Shokat post-doc 2020- UCSF

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Publications

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Zheng Q, Zhang Z, Guiley KZ, et al. (2024) Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature Chemical Biology
Malakoutikhah M, Mahran R, Gooran N, et al. (2023) Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes. Analytical Chemistry
Vasta JD, Peacock DM, Zheng Q, et al. (2022) KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nature Chemical Biology
Zheng Q, Peacock DM, Shokat KM. (2022) Drugging the Next Undruggable KRAS Allele-Gly12Asp. Journal of Medicinal Chemistry
Garnar-Wortzel L, Bishop TR, Kitamura S, et al. (2021) Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. Acs Central Science. 7: 815-830
Zheng Q, Xu H, Wang H, et al. (2021) Sulfur [F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis. Journal of the American Chemical Society
Kitamura S, Zheng Q, Woehl JL, et al. (2020) SuFEx-enabled high-throughput medicinal chemistry. Journal of the American Chemical Society
Zheng Q, Woehl JL, Kitamura S, et al. (2019) SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. Proceedings of the National Academy of Sciences of the United States of America
Barrow AS, Smedley CJ, Zheng Q, et al. (2019) The growing applications of SuFEx click chemistry. Chemical Society Reviews
Smedley CJ, Zheng Q, Gao B, et al. (2019) Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides. Angewandte Chemie (International Ed. in English)
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