Rahul V. Edwankar, Ph.D.
Affiliations: | 2010 | University of Wisconsin-Milwaukee, Milwaukee, WI | |
| 2012- | Chemistry | Broad Institute, Cambridge, MA, United States |
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Sign in to add mentor| James M. Cook | grad student | 2010 | UW-Milwaukee | |
| (Part I. Hz166, a novel gamma-aminobutyric acid (A) receptor subtype-selective ligand active against neuropathic pain Part II. The first enantiospecific, stereospecific total synthesis of the C-19 methyl substituted sarpagine indole alkaloids 19(S), 20(R),) | ||||
| Stuart L. Schreiber | post-doc | 2012- | Broad Institute | |
| Erik J. Alexanian | post-doc | 2010-2012 | UNC Chapel Hill | |
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| Edwankar RV, Edwankar CR, Deschamps JR, et al. (2014) General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine. The Journal of Organic Chemistry. 79: 10030-48 |
| Edwankar CR, Edwankar RV, Namjoshi OA, et al. (2013) Stereospecific approach to the synthesis of ring-A oxygenated sarpagine indole alkaloids. Total synthesis of the dimeric indole alkaloid P-(+)-dispegatrine and six other monomeric indole alkaloids. The Journal of Organic Chemistry. 78: 6471-87 |
| Brusoe AT, Edwankar RV, Alexanian EJ. (2012) Enantioselective intermolecular [2 + 2 + 2] cycloadditions of ene-allenes with allenoates. Organic Letters. 14: 6096-9 |
| Edwankar CR, Edwankar RV, Deschamps JR, et al. (2012) Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids. Angewandte Chemie (International Ed. in English). 51: 11762-5 |
| Edwankar RV, Edwankar CR, Namjoshi OA, et al. (2012) Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids. Journal of Natural Products. 75: 181-8 |
| Edwankar RV, Edwankar CR, Deschamps J, et al. (2011) Regiospecific, enantiospecific total synthesis of C-19 methyl substituted sarpagine alkaloids dihydroperaksine-17-al and dihydroperaksine. Organic Letters. 13: 5216-9 |
| Di Lio A, Benke D, Besson M, et al. (2011) HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. Neuropharmacology. 60: 626-32 |
| Fischer BD, Licata SC, Edwankar RV, et al. (2010) Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8 |
| Savić MM, Majumder S, Huang S, et al. (2010) Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86 |
| Edwankar CR, Edwankar RV, Namjoshi OA, et al. (2009) Recent progress in the total synthesis of indole alkaloids. Current Opinion in Drug Discovery & Development. 12: 752-71 |