Tao Huang, Ph.D.

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Bioorganic and Synthetic Organic Chemistry
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Timothy L. Macdonald grad student 2012 UVA
 (Synthesis of Conformation-Restricted Analogs of FTY720 as Sphingosine 1-Phosphate Receptor Pro-drugs.)
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Publications

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Kharel Y, Huang T, Salamon A, et al. (2023) Correction: Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal. 480: 2059-2060
Shrader CW, Foster D, Kharel Y, et al. (2023) Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 129516
Kharel Y, Huang T, Santos WL, et al. (2023) Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors. Slas Discovery : Advancing Life Sciences R & D
Burgio AL, Shrader CW, Kharel Y, et al. (2023) 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry
Tanaka S, Zheng S, Kharel Y, et al. (2022) Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Science Translational Medicine. 14: eabj2681
Fritzemeier R, Foster D, Peralta A, et al. (2022) Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry
Li H, Sibley CD, Kharel Y, et al. (2020) Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors. Bioorganic & Medicinal Chemistry. 30: 115941
Kharel Y, Huang T, Salamon A, et al. (2020) Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal
Kharel Y, Agah S, Huang T, et al. (2018) Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. Plos One. 13: e0192179
Liu C, Cui P, Huang T. (2017) Identification of cell cycle-regulated genes by convolutional neural network. Combinatorial Chemistry & High Throughput Screening
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