Liping Sun, Ph.D.

Nucleic Acid Chemistry

John-Stephen A. Taylor	grad student	2003	Washington University
(Use of base analogs to probe the mechanism of dipyrimidine photoproduct bypass by DNA replicative and damage bypass polymerases.)

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Vu B, Cannistraro VJ, Sun L, et al. (2006) DNA synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by yeast pol eta is highly nonmutagenic. Biochemistry. 45: 9327-35
Sun L, Zhang K, Zhou L, et al. (2003) Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T. Biochemistry. 42: 9431-7
Sun L, Wang M, Kool ET, et al. (2000) Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. Biochemistry. 39: 14603-10