Tomasz Sosinowski, Ph.D.

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
Signal transduction in lymphocytes
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Arthur Weiss grad student 2001 UCSF
 (Src -like adaptor protein negatively regulates T cell receptor signaling and thymocyte development.)
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Publications

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Wang Y, Sosinowski T, Novikov A, et al. (2019) How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Science Immunology. 4
Zhang L, Sosinowski T, Aaron R, et al. (2018) Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. Journal of Autoimmunity
Friend SF, Peterson LK, Treacy E, et al. (2013) The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation. Plos One. 8: e75200
Sosinowski T, White JT, Cross EW, et al. (2013) CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. Journal of Immunology (Baltimore, Md. : 1950). 190: 1936-47
Dragone LL, Myers MD, White C, et al. (2006) Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 103: 18202-7
Dragone LL, Myers MD, White C, et al. (2006) SRC-like adaptor protein regulates B cell development and function. Journal of Immunology (Baltimore, Md. : 1950). 176: 335-45
Myers MD, Sosinowski T, Dragone LL, et al. (2006) Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nature Immunology. 7: 57-66
Sosinowski T, Killeen N, Weiss A. (2001) The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 15: 457-66
Kratchmarova I, Sosinowski T, Weiss A, et al. (2001) Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene. 262: 267-73
Sosinowski T, Pandey A, Dixit VM, et al. (2000) Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. The Journal of Experimental Medicine. 191: 463-74
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