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Danilo O. Ortillo, Ph.D.

Affiliations: 
Michigan State University, East Lansing, MI 
Area:
Bioinorganic Chemistry; Mechanisms of Metalloenzyme-mediated Reactions; Mechanisms of Biological Radical Reactions; Bioremediation
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"Danilo Ortillo"
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Parents

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Joan Blanchette Broderick grad student 2006 Michigan State
 (The interactions of S-adenosylmethionine and pyruvate formate -lyase -activating enzyme: A radical activation.)

Children

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JJ Intano grad student

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Publications

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Ortillo DO, Broderick JB. (2014) Spectroscopic investigation of Pyruvate formate lyase-activating enzyme: A look into EPR, ENDOR and Mössabuer spectroscopy Research Journal of Applied Sciences, Engineering and Technology. 8: 1075-1097
Ye H, Jeong SY, Ghosh MC, et al. (2010) Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. The Journal of Clinical Investigation. 120: 1749-61
Yang J, Naik SG, Ortillo DO, et al. (2009) The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state. Biochemistry. 48: 9234-41
Mulder DW, Ortillo DO, Gardenghi DJ, et al. (2009) Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster. Biochemistry. 48: 6240-8
Murray LJ, Naik SG, Ortillo DO, et al. (2007) Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species. Journal of the American Chemical Society. 129: 14500-10
Walsby CJ, Ortillo D, Yang J, et al. (2005) Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily. Inorganic Chemistry. 44: 727-41
Broderick JB, Ortillo D, Broderick WE, et al. (2003) Poised for radical generation: Interaction of S-adenosylmethionine with a [4Fe4S] cluster Journal of Inorganic Biochemistry. 96: 104
Walsby CJ, Ortillo D, Broderick WE, et al. (2002) An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. Journal of the American Chemical Society. 124: 11270-1
Walsby CJ, Hong W, Broderick WE, et al. (2002) Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. Journal of the American Chemical Society. 124: 3143-51
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