Thomas F. Lerch, Ph.D.

Affiliations: 
Interdepartmental Biological Sciences Program Northwestern University, Evanston, IL 
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Theodore Jardetzky grad student 2007 Northwestern
 (Structural and biophysical studies into the regulation of activin signaling.)
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Xie Q, Spilman M, Meyer NL, et al. (2013) Electron microscopy analysis of a disaccharide analog complex reveals receptor interactions of adeno-associated virus. Journal of Structural Biology. 184: 129-35
Lerch TF, O'Donnell JK, Meyer NL, et al. (2012) Structure of AAV-DJ, a retargeted gene therapy vector: cryo-electron microscopy at 4.5 Ã… resolution. Structure (London, England : 1993). 20: 1310-20
Xie Q, Lerch TF, Meyer NL, et al. (2011) Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6). Virology. 420: 10-9
Lerch TF, Xie Q, Chapman MS. (2010) The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion. Virology. 403: 26-36
Lerch TF, Shimasaki S, Woodruff TK, et al. (2007) Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions Journal of Biological Chemistry. 282: 15930-15939
Lerch TF, Xu M, Jardetzky TS, et al. (2007) The structures that underlie normal reproductive function Molecular and Cellular Endocrinology. 267: 1-5
Lin SJ, Lerch TF, Cook RW, et al. (2006) The structural basis of TGF-β, bone morphogenetic protein, and activin ligand binding Reproduction. 132: 179-190
Thompson TB, Lerch TF, Cook RW, et al. (2005) The structure of the follistatin: Activin complex reveals antagonism of both type I and type II receptor binding Developmental Cell. 9: 535-543
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