Jason D. Galpin, Ph.D.
Affiliations: | University of British Columbia, Vancouver, Vancouver, BC, Canada |
Area:
Studies on novel enzyme mechanisms; epimerases and racemases; sugar nucleotide-modifying enzymes; isotope effects; inhibitor design; site-directed mutagenesisGoogle:
"Jason Galpin"Mean distance: 8.38 | S | N | B | C | P |
Parents
Sign in to add mentor| Martin E. Tanner | grad student | 2001 | UBC | |
| (An investigation of the electrophilic active site of histidine and phenylalanine ammonia -lyase.) | ||||
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Publications
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| Leisle L, Lam K, Dehghani-Ghahnaviyeh S, et al. (2022) Backbone amides are determinants of Cl selectivity in CLC ion channels. Nature Communications. 13: 7508 |
| Zhao C, Hong L, Galpin JD, et al. (2021) HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. The Journal of General Physiology. 153 |
| Leisle L, Xu Y, Fortea E, et al. (2020) Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9 |
| Leisle L, Xu Y, Fortea E, et al. (2020) Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Elife |
| Zhao C, Hong L, Riahi S, et al. (2020) Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain Biophysical Journal. 118: 111a |
| Zhao C, Hong L, Galpin JD, et al. (2019) Two-Pronged Aromatic Arginine-Mimics as Hv1 Proton Channel Inhibitors Biophysical Journal. 116: 540a |
| Infield DT, Matulef K, Galpin JD, et al. (2018) Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nature Communications. 9: 5055 |
| Infield DT, Lee EEL, Galpin JD, et al. (2018) Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. The Journal of General Physiology |
| Infield DT, Lueck JD, Galpin JD, et al. (2018) Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte. Scientific Reports. 8: 5166 |
| Infield DT, Goodchild SJ, Galpin JD, et al. (2018) Insights into Sodium Channel Gating Enabled by Transplantation of an Aryl Sulfonamide Drug Binding Site in Combination with Genetically-Encoded Cross Linking Biophysical Journal. 114 |